Neurogenin 3 Antibody (7): sc-136002

Neurogenin 3 Antibody (7) is a mouse monoclonal IgG1 antibody that detects Neurogenin 3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Neurogenin 3 is a crucial transcription factor belonging to the neurogenin family, which plays a significant role in the development of the nervous system and the differentiation of pancreatic islet cells. Neurogenin 3 is primarily located in discrete regions of developing neurons and the embryonic pancreatic islets of Langerhans, where anti-Neurogenin 3 antibody (7) can detect essential processes for the initial differentiation of the four islet cell types. Neurogenin 3′s cellular location enables orchestration of these critical cell types′ development, which are vital for insulin production and glucose regulation. Neurogenin 3 functions upstream of other transcription factors, such as Neuro D, in a basic helix-loop-helix cascade, activating Neuro D expression at the onset of islet cell differentiation. The regulation of these processes is crucial for maintaining proper metabolic function and preventing disorders such as diabetes. Neurogenin 3 (7) monoclonal antibody serves as an invaluable tool for researchers studying the mechanisms of neurogenesis and pancreatic development, providing insights into the intricate networks of transcriptional regulation that govern cell fate determination.

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Neurogenin 3 Antibody (7) References:

1. Neurogenin 3 is a key transcription factor for differentiation of the endocrine pancreas.  |  Watada, H. 2004. Endocr J. 51: 255-64. PMID: 15256770
2. Notch/neurogenin 3 signalling is involved in the neuritogenic actions of oestradiol in developing hippocampal neurones.  |  Ruiz-Palmero, I., et al. 2011. J Neuroendocrinol. 23: 355-64. PMID: 21251092
3. Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury.  |  Marzioni, M., et al. 2014. Hepatology. 60: 1324-35. PMID: 24925797
4. Co-ordinated regulation of neurogenin-3 expression in the maternal and fetal pancreas during pregnancy.  |  Søstrup, B., et al. 2014. Acta Obstet Gynecol Scand. 93: 1190-7. PMID: 25179808
5. Neurogenin 3-directed cre deletion of Tsc1 gene causes pancreatic acinar carcinoma.  |  Ding, L., et al. 2014. Neoplasia. 16: 909-17. PMID: 25425965
6. Revisiting the immunocytochemical detection of Neurogenin 3 expression in mouse and man.  |  Honoré, C., et al. 2016. Diabetes Obes Metab. 18 Suppl 1: 10-22. PMID: 27615127
7. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas.  |  Shamblott, MJ., et al. 2016. Cell Commun Signal. 14: 23. PMID: 27659207
8. PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration.  |  Zhu, Y., et al. 2017. Stem Cell Res Ther. 8: 240. PMID: 29096722
9. The Effects of Fecal Microbiota Transplantation on the Symptoms and the Duodenal Neurogenin 3, Musashi 1, and Enteroendocrine Cells in Patients With Diarrhea-Predominant Irritable Bowel Syndrome.  |  Mazzawi, T., et al. 2021. Front Cell Infect Microbiol. 11: 524851. PMID: 34055657
10. Arginine 65 methylation of Neurogenin 3 by PRMT1 is required for pancreatic endocrine development of hESCs.  |  Cho, G., et al. 2023. Exp Mol Med. 55: 1506-1519. PMID: 37394590

The preferred Neurogenin 3 antibody is Neurogenin 3 Antibody (E-8): sc-376607.