neurexin Iα Antibody (17): sc-136001

Neurexin Iα Antibody (17) is a mouse monoclonal IgG1 antibody that detects neurexin I alpha protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-neurexin I alpha antibody (17) is available as a non-conjugated format. Neurexins are critical neuronal cell surface proteins that play a vital role in synaptic function and plasticity, with neurexin I (NRXN1) being one of the most studied members of this family. Neurexin I alpha protein is primarily located at the presynaptic membrane, where interactions with neuroligins and other synaptic partners facilitate synapse formation and maintenance. This localization is crucial for proper neuronal communication, as synaptic structural and functional integrity helps establish essential neurotransmission and overall brain function. Additionally, neurexin I alpha undergoes alternative splicing, resulting in multiple isoforms that can differentially regulate synaptic signaling pathways. Binding to various ligands, including neurexophilins and α-latrotoxin, further underscores neurexin I alpha′s importance in synaptic transmission and modulation of synaptic strength. Understanding neurexin I alpha′s role in synaptic dynamics can provide insights into neurodevelopmental disorders and neurodegenerative diseases, making neurexin I alpha antibody (17) a valuable tool for researchers studying these critical processes.

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neurexin Iα Antibody (17) References:

1. Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels.  |  Poliak, S., et al. 1999. Neuron. 24: 1037-47. PMID: 10624965
2. Myelinating Schwann cells determine the internodal localization of Kv1.1, Kv1.2, Kvbeta2, and Caspr.  |  Arroyo, EJ., et al. 1999. J Neurocytol. 28: 333-47. PMID: 10739575
3. Expression of neurexin Ialpha splice variants in sympathetic neurons: selective changes during differentiation and in response to neurotrophins.  |  Patzke, H. and Ernsberger, U. 2000. Mol Cell Neurosci. 15: 561-72. PMID: 10860582
4. alpha-latrotoxin forms calcium-permeable membrane pores via interactions with latrophilin or neurexin.  |  Van Renterghem, C., et al. 2000. Eur J Neurosci. 12: 3953-62. PMID: 11069591
5. alpha-Latrotoxin and its receptors.  |  Ushkaryov, YA., et al. 2008. Handb Exp Pharmacol. 171-206. PMID: 18064415
6. Structures, alternative splicing, and neurexin binding of multiple neuroligins.  |  Ichtchenko, K., et al. 1996. J Biol Chem. 271: 2676-82. PMID: 8576240
7. Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions.  |  Peles, E., et al. 1997. EMBO J. 16: 978-88. PMID: 9118959
8. Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules.  |  Nguyen, T. and Südhof, TC. 1997. J Biol Chem. 272: 26032-9. PMID: 9325340
9. The axonal membrane protein Caspr, a homologue of neurexin IV, is a component of the septate-like paranodal junctions that assemble during myelination.  |  Einheber, S., et al. 1997. J Cell Biol. 139: 1495-506. PMID: 9396755
10. The making of neurexins.  |  Missler, M., et al. 1998. J Neurochem. 71: 1339-47. PMID: 9751164
11. Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis.  |  Grifman, M., et al. 1998. Proc Natl Acad Sci U S A. 95: 13935-40. PMID: 9811904
12. Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.  |  Missler, M., et al. 1998. J Biol Chem. 273: 34716-23. PMID: 9856994

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-neurexin Iα Antibody (17) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-neurexin Iα Antibody (17) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

neurexin Iα Antibody (17) Specifications

Alternate Product Name: neurexin Iα

Product Clone Name: 17

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 1063-1184

Epitope Target: neurexin Iα

Epitope Species: rat

Product Reactivity/Detection: neurexin Iα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for neurexin Iα Antibody (17): N/A