Neuregulin-4 Antibody (C4): sc-517451
- Neuregulin-4 Antibody (C4) is a mouse monoclonal IgG2b κ Neuregulin-4 antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 1-62 of Neuregulin-4 of human origin
- recommended for detection of Neuregulin-4 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Neuregulin-4 Antibody (C4). This work is in progress.
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Neuregulin-4 Antibody (C4) is a mouse monoclonal IgG2b kappa light chain antibody that detects Neuregulin-4 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Neuregulin-4 antibody (C4) is available as a non-conjugated format. Neuregulin-4, a member of the neuregulin family, plays a crucial role in the development and function of various tissues, particularly in the pancreas where Neuregulin-4 is predominantly expressed. Neuregulin-4 is involved in the regulation of cell signaling pathways that influence cell growth, differentiation, and survival, making Neuregulin-4 essential for maintaining pancreatic function and potentially impacting metabolic processes. The neuregulin family, which arises from a single gene through alternative splicing, interacts with ErbB receptor tyrosine kinases, specifically activating ErbB-3 and ErbB-4, which are vital for cellular communication and development. Neuregulin-4′s ability to modulate these pathways highlights Neuregulin-4′s importance in both normal physiology and disease states, including potential implications in pancreatic disorders.
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Neuregulin-4 Antibody (C4) References:
- Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. | Harari, D., et al. 1999. Oncogene. 18: 2681-9. PMID: 10348342
- Identification of heregulin, a specific activator of p185erbB2. | Holmes, WE., et al. 1992. Science. 256: 1205-10. PMID: 1350381
- Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. | Coussens, L., et al. 1985. Science. 230: 1132-9. PMID: 2999974
- Growth factor receptor tyrosine kinases. | Yarden, Y. and Ullrich, A. 1988. Annu Rev Biochem. 57: 443-78. PMID: 3052279
- Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin. | Sliwkowski, MX., et al. 1994. J Biol Chem. 269: 14661-5. PMID: 7514177
- Heregulin induces tyrosine phosphorylation of HER4/p180erbB4. | Plowman, GD., et al. 1993. Nature. 366: 473-5. PMID: 7902537
- A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. | Carraway, KL. and Cantley, LC. 1994. Cell. 78: 5-8. PMID: 8033211
- Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. | Marchionni, MA., et al. 1993. Nature. 362: 312-8. PMID: 8096067
- The erbB3 gene product is a receptor for heregulin. | Carraway, KL., et al. 1994. J Biol Chem. 269: 14303-6. PMID: 8188716
- Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. | Carraway, KL., et al. 1997. Nature. 387: 512-6. PMID: 9168115
- Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. | Zhang, D., et al. 1997. Proc Natl Acad Sci U S A. 94: 9562-7. PMID: 9275162
- NRG-3 in human breast cancers: activation of multiple erbB family proteins. | Hijazi, MM., et al. 1998. Int J Oncol. 13: 1061-7. PMID: 9772300
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Neuregulin-4 Antibody (C4) | sc-517451 | 100 µg/ml | $322.00 |