netrin-4 Antibody (A-7): sc-365280

netrin-4 Antibody (A-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects netrin-4 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-netrin-4 antibody (A-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Netrin-4, also known as β-netrin, plays a crucial role in guiding axonal growth and cell migration during development, which is vital for proper neural and vascular formation. Netrin-4 is primarily located in the basement membranes of the vasculature, lateral olfactory tract, kidney, and ovary, highlighting its importance in tissue architecture and function. The gene encoding netrin-4 is situated on chromosome 12q22-q23, and netrin-4 expression is notably high in various human tissues, including the cerebral cortex, hippocampus, amygdaloid nuclei, and Purkinje cells. Netrin-4 interaction with other proteins, such as the laminin β chains, underscores its significance in cellular signaling pathways that regulate developmental processes. Understanding netrin-4 function and localization is essential for elucidating its role in health and disease, particularly in conditions related to neural and vascular development.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

netrin-4 Antibody (A-7) References:

1. Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors.  |  Wang, H., et al. 1999. J Neurosci. 19: 4938-47. PMID: 10366627
2. A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin: identification, expression, and functional characterization.  |  Koch, M., et al. 2000. J Cell Biol. 151: 221-34. PMID: 11038171
3. Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis.  |  Liu, Y., et al. 2004. Curr Biol. 14: 897-905. PMID: 15186747
4. Identification of a novel alternative splicing form of human netrin-4 and analyzing the expression patterns in adult rat brain.  |  Zhang, C., et al. 2004. Brain Res Mol Brain Res. 130: 68-80. PMID: 15519678
5. Netrin-4 Promotes Differentiation and Migration of Osteoblasts.  |  Enoki, Y., et al. 2017. In Vivo. 31: 793-799. PMID: 28882944
6. Netrin-4 expression by human endothelial cells inhibits endothelial inflammation and senescence.  |  Zhang, H., et al. 2021. Int J Biochem Cell Biol. 134: 105960. PMID: 33636396
7. Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy.  |  Crespo-Garcia, S., et al. 2021. Int J Mol Sci. 22: PMID: 33923095
8. Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors.  |  Dong, F., et al. 2023. Cell Mol Neurobiol. 43: 1663-1683. PMID: 36350538
9. Association of maternal serum Netrin-1 and Netrin-4 levels with placenta accreta spectrum.  |  Kaya, S., et al. 2023. Eur Rev Med Pharmacol Sci. 27: 4594-4600. PMID: 37259741
10. Netrin-4 synthesized in satellite cell-derived myoblasts stimulates autonomous fusion.  |  Maeno, T., et al. 2023. Exp Cell Res. 430: 113698. PMID: 37437770
11. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord.  |  Kennedy, TE., et al. 1994. Cell. 78: 425-35. PMID: 8062385
12. The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3.  |  Van Raay, TJ., et al. 1997. Genomics. 41: 279-82. PMID: 9143507

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-netrin-4 Antibody (A-7) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-netrin-4 Antibody (A-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

netrin-4 Antibody (A-7) Specifications

Alternate Product Name: netrin-4

Product Clone Name: A-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 399-628

Epitope Target: netrin-4

Epitope Species: human

Product Reactivity/Detection: netrin-4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for netrin-4 Antibody (A-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin