NETO2 Antibody (3E3): sc-517104
- NETO2 Antibody (3E3) is a mouse monoclonal IgG2a κ NETO2 antibody provided at 100 µg/ml
- raised against amino acids 426-525 representing partial length NETO2 of human origin
- recommended for detection of NETO2 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NETO2 Antibody (3E3). This work is in progress.
NETO2 Antibody (3E3) is a mouse monoclonal IgG2a kappa light chain antibody that detects NETO2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-NETO2 antibody (3E3) is available as the non-conjugated format. NETO2, also known as neuropilin (NRP) and tolloid (TLL)-like 2, or BTCL2, is a 525 amino acid single-pass type I membrane protein characterized by two CUB domains and one LDL-receptor class A domain. NETO2 is predominantly located in the brain, where NETO2 plays a crucial role in the development and maintenance of neuronal circuitry, essential for proper brain function and communication between neurons. The gene encoding NETO2 is situated on human chromosome 16, a region linked to various genetic disorders, including giant axonal neuropathy and Rubinstein-Taybi syndrome. Multiple alternatively spliced isoforms of NETO2 suggest a complex regulatory mechanism that may influence neuronal development. Understanding NETO2′s role in neuronal circuitry is vital, as disruptions in NETO2 function could contribute to neurological disorders, highlighting NETO2′s importance in maintaining cognitive health and neurological integrity.
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NETO2 Antibody (3E3) References:
- Neto2 modulation of kainate receptors with different subunit compositions. | Straub, C., et al. 2011. J Neurosci. 31: 8078-82. PMID: 21632929
- Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures. | Mahadevan, V., et al. 2015. Front Cell Neurosci. 9: 368. PMID: 26441539
- Neto2 Influences on Kainate Receptor Pharmacology and Function. | Han, L., et al. 2016. Basic Clin Pharmacol Toxicol. 119: 141-8. PMID: 26928870
- Kainate receptor auxiliary subunit NETO2 is required for normal fear expression and extinction. | Mennesson, M., et al. 2019. Neuropsychopharmacology. 44: 1855-1866. PMID: 30770891
- Reducing NETO2 expression prevents human nasopharyngeal carcinoma (NPC) progression by suppressing metastasis and inducing apoptosis. | He, AR., et al. 2019. Biochem Biophys Res Commun. 513: 494-501. PMID: 30975469
- NETO2 promotes pancreatic cancer cell proliferation, invasion and migration via activation of the STAT3 signaling pathway. | Li, Y., et al. 2019. Cancer Manag Res. 11: 5147-5156. PMID: 31239769
- NETO2 Is Deregulated in Breast, Prostate, and Colorectal Cancer and Participates in Cellular Signaling. | Fedorova, MS., et al. 2020. Front Genet. 11: 594933. PMID: 33362854
- NETO2 promotes esophageal cancer progression by inducing proliferation and metastasis via PI3K/AKT and ERK pathway. | Xu, JC., et al. 2021. Int J Biol Sci. 17: 259-270. PMID: 33390848
- Kainate receptor modulation by NETO2. | He, L., et al. 2021. Nature. 599: 325-329. PMID: 34552241
- TYMSOS-miR-101-3p-NETO2 axis promotes osteosarcoma progression. | Zhang, Z., et al. 2023. Mol Cell Probes. 67: 101887. PMID: 36509232
- Glioma-derived LRIG3 interacts with NETO2 in tumor-associated macrophages to modulate microenvironment and suppress tumor growth. | Li, Y., et al. 2023. Cell Death Dis. 14: 28. PMID: 36639372
- NETO2 promotes melanoma progression via activation of the Ca2+/CaMKII signaling pathway. | Zhu, S., et al. 2023. Front Med. 17: 263-274. PMID: 36738427
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NETO2 Antibody (3E3) | sc-517104 | 100 µg/ml | $322.00 |