NETO2 Activators
NETO2 activators are a class of chemical compounds that play a crucial role in modulating neuronal excitability and synaptic plasticity within the central nervous system. These compounds primarily target the NETO2 protein, also known as neuropilin and tolloid-like 2, which is a multifunctional protein expressed in various regions of the brain, including the hippocampus and cortex. NETO2 activators are known for their ability to enhance the function of ionotropic glutamate receptors, particularly AMPA receptors, by interacting with the auxiliary subunits of these receptors.
NETO2 activators work by binding to NETO2 and altering its interaction with AMPA receptors. NETO2 normally acts as a modulator of AMPA receptor trafficking and function, and its interaction with these receptors can have a profound impact on synaptic strength and plasticity. When NETO2 activators bind to NETO2, they can either stabilize or promote the assembly of AMPA receptors, leading to an increase in their surface expression and synaptic localization. This results in enhanced synaptic transmission and the strengthening of excitatory synaptic connections. By facilitating the trafficking and synaptic incorporation of AMPA receptors, NETO2 activators contribute to the fine-tuning of neuronal network activity, which is essential for various cognitive processes such as learning and memory. Additionally, these compounds have generated significant interest in neuroscience research due to their implications in understanding the molecular mechanisms underlying synaptic plasticity and neuronal circuit function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. Elevated cAMP can stimulate the protein kinase A (PKA) pathway, potentially leading to the upregulation of genes like NETO2 in neurons. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol, has been shown to modulate several signaling pathways in cells. It might upregulate NETO2 as part of its neuroprotective and anti-inflammatory properties. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate gene expression in neurons. Its anti-inflammatory and antioxidant properties suggest a potential role in inducing NETO2 expression to regulate synaptic activities. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane has neuroprotective effects. It might upregulate NETO2 expression as part of its mechanism to combat oxidative stress in neural cells. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine can modulate neuronal activity and gene expression. Its potential to upregulate NETO2 might be linked to its role in enhancing cognitive function and synaptic plasticity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium affects several cellular processes and pathways. It might induce NETO2 expression as a potential mechanism in its role in neuroprotection and synaptic modulation. | ||||||