neogenin Antibody (G-7): sc-514872

neogenin Antibody (G-7) is a mouse monoclonal IgM kappa antibody that detects neogenin protein of mouse and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). neogenin (G-7) antibody is available in both non-conjugated and various conjugated forms, including fluorescein isothiocyanate (FITC), providing versatility for different experimental needs. Neogenin (NGN) plays a crucial role in the development of the nervous system and gastrointestinal tract, acting as a cell adhesion molecule that facilitates the migration and differentiation of neural progenitor cells. NGN′s importance is underscored by structural similarity to the deleted in colorectal cancer (DCC) protein, which is implicated in tumor suppression and neural development. The interaction between NGN and DCC suggests that these proteins may work together to ensure proper formation of the central nervous system. Notably, NGN is expressed in a wide range of normal tissues and is also present at significant levels in various cancer tissues, highlighting NGN′s potential as a biomarker for cancer research. As a member of the N-CAM family, NGN is found on the surfaces of growing nerve cells and in several developing embryonic tissues, making NGN a valuable target for studies focused on neural development and cancer biology.

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neogenin Antibody (G-7) References:

1. Emerging roles for neogenin and its ligands in CNS development.  |  De Vries, M. and Cooper, HM. 2008. J Neurochem. 106: 1483-92. PMID: 18485097
2. Identification of a chromosome 18q gene that is altered in colorectal cancers.  |  Fearon, ER., et al. 1990. Science. 247: 49-56. PMID: 2294591
3. The roles of RGMa-neogenin signaling in inflammation and angiogenesis.  |  Fujita, Y. and Yamashita, T. 2017. Inflamm Regen. 37: 6. PMID: 29259705
4. Transsynaptic cerebellin 4-neogenin 1 signaling mediates LTP in the mouse dentate gyrus.  |  Liakath-Ali, K., et al. 2022. Proc Natl Acad Sci U S A. 119: e2123421119. PMID: 35544694
5. Neogenin pathway positively regulates fibronectin production by glomerular mesangial cells.  |  Chaudhari, S., et al. 2022. Am J Physiol Cell Physiol. 323: C226-C235. PMID: 35704698
6. Macrophage neogenin deficiency exacerbates myocardial remodeling and inflammation after acute myocardial infarction through JAK1-STAT1 signaling.  |  Zhang, J., et al. 2023. Cell Mol Life Sci. 80: 324. PMID: 37824022
7. Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer.  |  Vielmetter, J., et al. 1994. J Cell Biol. 127: 2009-20. PMID: 7806578
8. The DCC gene product in cellular differentiation and colorectal tumorigenesis.  |  Hedrick, L., et al. 1994. Genes Dev. 8: 1174-83. PMID: 7926722
9. Deleted in Colorectal Cancer (DCC) encodes a netrin receptor.  |  Keino-Masu, K., et al. 1996. Cell. 87: 175-85. PMID: 8861902
10. Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23.  |  Vielmetter, J., et al. 1997. Genomics. 41: 414-21. PMID: 9169140
11. Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis.  |  Keeling, SL., et al. 1997. Oncogene. 15: 691-700. PMID: 9264410
12. The expression patterns of guidance receptors, DCC and Neogenin, are spatially and temporally distinct throughout mouse embryogenesis.  |  Gad, JM., et al. 1997. Dev Biol. 192: 258-73. PMID: 9441666

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-neogenin Antibody (G-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-neogenin Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

neogenin Antibody (G-7) Specifications

Alternate Product Name: NEO1

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1171-1345

Epitope Target: neogenin

Epitope Species: human

Product Reactivity/Detection: neogenin

Species Reactivity/Detection: mouse, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for neogenin Antibody (G-7): FITC: Fluoroscein