NELL2 Antibody (AT13E7): sc-517415
- NELL2 Antibody (AT13E7) is a mouse monoclonal IgG2b κ provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 30-258 of NELL2 of human origin
- recommended for detection of NELL2 of mouse, rat and human origin by WB and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NELL2 Antibody (AT13E7). This work is in progress.
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NELL2 Antibody (AT13E7) is a mouse monoclonal IgG2b light chain antibody that detects NELL2 in mouse, rat, and human samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). NELL2, also known as neural epidermal growth factor-like 2 or NEL-related protein 2, is a secreted glycoprotein characterized by its unique structure, which includes one N-terminal TSP-like domain, five von Willebrand factor C domains, and six EGF-like repeats that facilitate calcium binding. This structural composition enables NELL2 to participate in calcium-dependent intracellular signaling pathways, which are vital for various cellular processes, including growth and differentiation. NELL2 typically exists as a homotrimer associated with the endoplasmic reticulum and is predominantly expressed in neurons, where NELL2 may function as a trophic factor, promoting neuronal survival and development. Additionally, an alternative isoform of NELL2, which lacks the signal peptide necessary for secretion, remains in the cytosol and interacts with protein kinase C beta I, further underscoring NELL2′s multifaceted roles in cellular signaling and function. Anti-NELL2 antibody (AT13E7) is an essential tool for researchers investigating the complex mechanisms of neuronal signaling and the implications of NELL2 in neurodevelopmental processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NELL2 Antibody (AT13E7) | sc-517415 | 100 µg/ml | $322.00 |