NEIL1 Antibody (D-1): sc-271164
- NEIL1 Antibody (D-1) is a mouse monoclonal IgG1 κ NEIL1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-49 mapping at the N-terminus of NEIL1 of human origin
- NEIL1 Antibody (D-1) is recommended for detection of NEIL1 of human origin by WB, IP, IF and ELISA
- Anti-NEIL1 Antibody (D-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-271164 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for NEIL1 Antibody (D-1) for WB applications. These reagents are now offered in bundles with NEIL1 Antibody (D-1) (see ordering information below).
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NEIL1 Antibody (D-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects NEIL1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-NEIL1 antibody (D-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NEIL1, also known as Endonuclease VIII-like 1, plays a crucial role in repairing oxidative DNA damage, which is vital for maintaining genomic stability and preventing mutations that can lead to cancer. As a member of the FPG family of proteins, NEIL1 functions as a DNA glycosylase, recognizing and excising damaged bases to create abasic sites that can be further processed by other repair mechanisms. NEIL1 is ubiquitously expressed and shows increased expression during the S-phase of the cell cycle, highlighting its importance in DNA repair during DNA replication. In contrast, NEIL2 and NEIL3 exhibit more restricted expression patterns, with NEIL2 primarily found in the testis, heart, skeletal muscle, placenta, brain, kidney, and liver, while NEIL3 is predominantly detected in the thymus and testis. NEIL1′s ability to interact with other proteins involved in DNA repair pathways underscores its significance in cellular responses to DNA damage, making NEIL1 (D-1) monoclonal antibody an essential tool for researchers studying DNA repair mechanisms and their implications in disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NEIL1 Antibody (D-1) References:
- Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions. | Hazra, TK., et al. 2002. J Biol Chem. 277: 30417-20. PMID: 12097317
- Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. | Dou, H., et al. 2003. J Biol Chem. 278: 49679-84. PMID: 14522990
- Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer. | Shinmura, K., et al. 2004. Carcinogenesis. 25: 2311-7. PMID: 15319300
- Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein. | Das, A., et al. 2004. J Biol Chem. 279: 47132-8. PMID: 15339932
- Stimulation of DNA glycosylase activity of OGG1 by NEIL1: functional collaboration between two human DNA glycosylases. | Mokkapati, SK., et al. 2004. Biochemistry. 43: 11596-604. PMID: 15350146
- Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2. | Hailer, MK., et al. 2005. DNA Repair (Amst). 4: 41-50. PMID: 15533836
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NEIL1 Antibody (D-1) | sc-271164 | 200 µg/ml | $322.00 | |||
NEIL1 Antibody (D-1): m-IgG Fc BP-HRP Bundle | sc-527214 | 200 µg Ab; 10 µg BP | $361.00 | |||
NEIL1 Antibody (D-1): m-IgG1 BP-HRP Bundle | sc-532587 | 200 µg Ab; 20 µg BP | $361.00 | |||
NEIL1 Antibody (D-1) X | sc-271164 X | 200 µg/0.1 ml | $322.00 | |||
NEIL1 Antibody (D-1) AC | sc-271164 AC | 500 µg/ml, 25% agarose | $424.00 | |||
NEIL1 Antibody (D-1) HRP | sc-271164 HRP | 200 µg/ml | $322.00 | |||
NEIL1 Antibody (D-1) FITC | sc-271164 FITC | 200 µg/ml | $336.00 | |||
NEIL1 Antibody (D-1) PE | sc-271164 PE | 200 µg/ml | $349.00 | |||
NEIL1 Antibody (D-1) Alexa Fluor® 488 | sc-271164 AF488 | 200 µg/ml | $364.00 | |||
NEIL1 Antibody (D-1) Alexa Fluor® 546 | sc-271164 AF546 | 200 µg/ml | $364.00 | |||
NEIL1 Antibody (D-1) Alexa Fluor® 594 | sc-271164 AF594 | 200 µg/ml | $364.00 | |||
NEIL1 Antibody (D-1) Alexa Fluor® 647 | sc-271164 AF647 | 200 µg/ml | $364.00 | |||
NEIL1 Antibody (D-1) Alexa Fluor® 680 | sc-271164 AF680 | 200 µg/ml | $364.00 | |||
NEIL1 Antibody (D-1) Alexa Fluor® 790 | sc-271164 AF790 | 200 µg/ml | $364.00 |