Nebulin Antibody (1F4): sc-293370

Nebulin Antibody (1F4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Nebulin protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Nebulin antibody (1F4) is available as the non-conjugated format, which plays a crucial role in muscle function by acting as a molecular ruler that regulates thin filament length in striated muscle. Nebulin (1F4) antibody targets a large filamentous protein essential for maintaining sarcomere structural integrity, the fundamental unit of muscle contraction, and its precise length is vital for optimal muscle performance. Nebulin (1F4) monoclonal antibody recognizes a protein predominantly localized in skeletal muscle, where it interacts with actin and other actin-binding proteins, ensuring proper filament assembly and stability. Several isoforms of Nebulin arise from alternative splicing, allowing for tissue-specific functions and adaptations. The ability of Nebulin to modulate actin dynamics is critical for muscle development and function, making it a significant target for research in muscle-related diseases and conditions.

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Nebulin Antibody (1F4) References:

1. Developmental regulation of villin gene expression in the epithelial cell lineages of mouse digestive and urogenital tracts.  |  Maunoury, R., et al. 1992. Development. 115: 717-28. PMID: 1425351
2. Caldesmon binds to smooth muscle myosin and myosin rod and crosslinks thick filaments to actin filaments.  |  Marston, S., et al. 1992. J Muscle Res Cell Motil. 13: 206-18. PMID: 1534566
3. Actin-binding and dimerization domains of HeLa cell filamin.  |  Weihing, RR. 1988. Biochemistry. 27: 1865-9. PMID: 3378035
4. The complete primary structure of human nebulin and its correlation to muscle structure.  |  Labeit, S. and Kolmerer, B. 1995. J Mol Biol. 248: 308-15. PMID: 7739042
5. Multiple-sited interaction of caldesmon with Ca(2+)-calmodulin.  |  Huber, PA., et al. 1996. Biochem J. 316 (Pt 2): 413-20. PMID: 8687382
6. cDNA cloning of mouse nebulin. Evidence that the nebulin-coding sequence is highly conserved among vertebrates.  |  Zhang, JQ., et al. 1996. Eur J Biochem. 239: 835-41. PMID: 8774733

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Nebulin Antibody (1F4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Nebulin Antibody (1F4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Nebulin Antibody (1F4) Specifications

Alternate Product Name: Nebulin

Product Clone Name: 1F4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2108-2217

Epitope Target: Nebulin

Epitope Species: human

Product Reactivity/Detection: Nebulin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Nebulin Antibody (1F4): N/A