NDUFS4 Antibody (1-E-4): sc-100567

NDUFS4 Antibody (1-E-4) is a mouse monoclonal IgG2a antibody that detects NDUFS4 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). NDUFS4, also known as NADH dehydrogenase (ubiquinone) Fe-S protein 4 or AQDQ, is a crucial accessory subunit of Complex I in the mitochondrial inner membrane, which plays a vital role in cellular respiration by facilitating the transfer of electrons from NADH to ubiquinone. This process is essential for maintaining the electrochemical proton gradient necessary for ATP synthesis, making NDUFS4 integral to energy production in cells. NDUFS4′s location in the mitochondrial inner membrane ensures that the electron transport chain operates efficiently, directly influencing cellular metabolism and energy availability. Mutations in the NDUFS4 gene can lead to Complex I mitochondrial respiratory chain deficiency, resulting in severe clinical manifestations such as cardiomyopathy, myopathy, liver failure, and neurological disorders, underscoring NDUFS4′s significance in human health. Anti-NDUFS4 antibody (1-E-4) is an invaluable tool for researchers studying mitochondrial function and related pathologies, providing insights into the molecular mechanisms underlying energy metabolism and its associated disorders.

The preferred NDUFS4 antibody is NDUFS4 Antibody (A-7): sc-514002.