NDUFB6 Antibody (B-2): sc-515596

NDUFB6 Antibody (B-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects NDUFB6 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-NDUFB6 antibody (B-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NDUFB6, also known as NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 or CI-B17, is a crucial component of the mitochondrial respiratory chain, specifically involved in the electron transport chain. This 128 amino acid single-pass membrane protein is located on the matrix side of the mitochondrial inner membrane, where NDUFB6 plays a vital role in cellular energy production by facilitating the transfer of electrons from NADH to ubiquinone. Proper functioning of NDUFB6 is essential for maintaining mitochondrial health and energy metabolism; dysfunction can lead to various mitochondrial diseases and metabolic disorders. NDUFB6 is encoded by a gene located on human chromosome 9p21.1, a region associated with several genetic conditions, including hereditary hemorrhagic telangiectasia and familial dysautonomia. NDUFB6 (B-2) monoclonal antibody′s ability to effectively detect this important protein makes NDUFB6 (B-2) antibody a valuable tool for researchers studying mitochondrial function and related pathologies.

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NDUFB6 Antibody (B-2) References:

1. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.  |  Murray, J., et al. 2003. J Biol Chem. 278: 13619-22. PMID: 12611891
2. Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p.  |  Zhuang, H., et al. 2006. Arthritis Rheum. 54: 1573-9. PMID: 16645992
3. Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease).  |  Cottin, V., et al. 2007. Respiration. 74: 361-78. PMID: 17641482
4. Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemia.  |  Burmeister, T., et al. 2007. Haematologica. 92: 1699-702. PMID: 18055996
5. Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing.  |  Gold-von Simson, G., et al. 2009. Pediatr Res. 65: 341-6. PMID: 19033881
6. Organization of the amplified type I interferon gene cluster and associated chromosome regions in the interphase nucleus of human osteosarcoma cells.  |  Zeitz, MJ., et al. 2009. Chromosome Res. 17: 305-19. PMID: 19283497
7. Neuroimaging supports central pathology in familial dysautonomia.  |  Axelrod, FB., et al. 2010. J Neurol. 257: 198-206. PMID: 19705052
8. The NDUFB6 subunit of the mitochondrial respiratory chain complex I is required for electron transfer activity: a proof of principle study on stable and controlled RNA interference in human cell lines.  |  Loublier, S., et al. 2011. Biochem Biophys Res Commun. 414: 367-72. PMID: 21964293
9. Downregulation of NDUFB6 due to 9p24.1-p13.3 loss is implicated in metastatic clear cell renal cell carcinoma.  |  Narimatsu, T., et al. 2015. Cancer Med. 4: 112-24. PMID: 25315157
10. OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.  |  Wu, Z., et al. 2021. EMBO Rep. 22: e50827. PMID: 33314701
11. NDUFB6 Polymorphism Is Associated With Physical Activity-Mediated Metabolic Changes in Type 2 Diabetes.  |  Pesta, D., et al. 2021. Front Endocrinol (Lausanne). 12: 693683. PMID: 34659107
12. Molecular characterization and mutational analysis of the human B17 subunit of the mitochondrial respiratory chain complex I.  |  Smeitink, J., et al. 1998. Hum Genet. 103: 245-50. PMID: 9760212

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NDUFB6 Antibody (B-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-NDUFB6 Antibody (B-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NDUFB6 Antibody (B-2) Specifications

Alternate Product Name: NDUFB6

Product Clone Name: B-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 99-115

Epitope Target: NDUFB6

Epitope Species: human

Product Reactivity/Detection: NDUFB6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for NDUFB6 Antibody (B-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin