NDUFB3 Antibody (G-9): sc-398174

NDUFB3 Antibody (G-9) is a mouse monoclonal IgG1 antibody that detects NDUFB3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NDUFB3, also known as B12, is a crucial 98 amino acid hydrophobic protein that plays a significant role as an accessory subunit of Complex I in the mitochondrial inner membrane. NDUFB3 is essential for the proper functioning of the electron transport chain, facilitating the transfer of electrons from NADH to ubiquinone, ultimately contributing to ATP synthesis by creating an electrochemical proton gradient. The structural integrity of NDUFB3 is vital, as NDUFB3 is part of a complex assembly of at least 45 different subunits that form the L-shaped structure of Complex I. Disruptions in the structure or function of NDUFB3 can lead to impaired mitochondrial respiration and energy production, which are critical for cellular metabolism and overall cellular health. Anti-NDUFB3 antibody (G-9) is an invaluable tool for researchers studying mitochondrial function, energy metabolism, and related pathologies, providing insights into the intricate mechanisms of cellular respiration and the potential implications of mitochondrial dysfunction in various diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

NDUFB3 Antibody (G-9) References:

1. Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing.  |  Haack, TB., et al. 2012. J Med Genet. 49: 277-83. PMID: 22499348
2. Potential hippocampal genes and pathways involved in Alzheimer's disease: a bioinformatic analysis.  |  Zhang, L., et al. 2015. Genet Mol Res. 14: 7218-32. PMID: 26125932
3. Reduced Mitochondrial Activity is Early and Steady in the Entorhinal Cortex but it is Mainly Unmodified in the Frontal Cortex in Alzheimer's Disease.  |  Armand-Ugon, M., et al. 2017. Curr Alzheimer Res. 14: 1327-1334. PMID: 28474567
4. Maternal High Fat Diet and in-Utero Metformin Exposure Significantly Impact upon the Fetal Renal Proteome of Male Mice.  |  Nüsken, E., et al. 2019. J Clin Med. 8: PMID: 31083566
5. Gene Co-expression Network Analysis for Identifying Modules and Functionally Enriched Pathways in Vitiligo Disease: A Systems Biology Study.  |  Derakhshani, A., et al. 2020. Iran J Allergy Asthma Immunol. 19: 517-528. PMID: 33463119
6. Identification of key genes associated with sepsis patients infected by staphylococcus aureus through weighted gene co-expression network analysis.  |  Wu, H., et al. 2021. Am J Transl Res. 13: 13579-13589. PMID: 35035698
7. Curcumin prevents proteins expression changes of oxidative phosphorylation, cellular stress response, and lipid metabolism proteins in liver of mice fed a high-fructose diet.  |  Silva-Gaona, OG., et al. 2022. J Proteomics. 263: 104595. PMID: 35490921
8. 2,3',4,4',5-Pentachlorobiphenyl induced thyroid dysfunction by increasing mitochondrial oxidative stress.  |  Xu, W., et al. 2022. J Toxicol Sci. 47: 555-565. PMID: 36450500
9. Unveiling shared therapeutic targets and pathological pathways between coronary artery disease and major depressive disorder through bioinformatics analysis.  |  Hu, M., et al. 2024. Sci Rep. 14: 29365. PMID: 39592804
10. Lactational high weight loss impairs follicular development by causing mitochondrial dysfunction of ovarian cells in sows and mitigated by butyrate supplement.  |  Liu, K., et al. 2025. J Adv Res.. PMID: 39892609

The preferred NDUFB3 antibody is NDUFB3 Antibody (F-12): sc-393351.