NDUFA8 Antibody (C-6): sc-398097
- NDUFA8 Antibody (C-6) is a mouse monoclonal IgG2a κ NDUFA8 antibody provided at 200 µg/ml
- raised against amino acids 1-172 representing full length NDUFA8 of human origin
- NDUFA8 Antibody (C-6) is recommended for detection of NDUFA8 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-NDUFA8 Antibody (C-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for NDUFA8 Antibody (C-6) for WB applications. These reagents are now offered in bundles with NDUFA8 Antibody (C-6) (see ordering information below).
NDUFA8 Antibody (C-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects NDUFA8 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NDUFA8 (C-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NDUFA8, also known as complex I-PGIV or PGIV, is a crucial 172 amino acid mitochondrial protein that plays a vital role as a subunit of the NADH dehydrogenase complex (Complex I) in the mitochondrial respiratory chain. NDUFA8 is essential for transferring electrons from NADH to the respiratory chain, a process fundamental for ATP production and cellular energy metabolism. NDUFA8 is predominantly expressed in heart and skeletal muscle tissues, where NDUFA8′s function is particularly critical due to the high energy demands of these tissues. NDUFA8 contains two conserved CHCH domains, which are important for structural integrity and function. The gene encoding NDUFA8 is located on human chromosome 9, a region associated with various genetic disorders, including hereditary hemorrhagic telangiectasia and familial dysautonomia, highlighting NDUFA8′s importance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NDUFA8 Antibody (C-6) References:
- Human mitochondrial complex I in health and disease. | Smeitink, J. and van den Heuvel, L. 1999. Am J Hum Genet. 64: 1505-10. PMID: 10330338
- The consensus coding sequences of human breast and colorectal cancers. | Sjöblom, T., et al. 2006. Science. 314: 268-74. PMID: 16959974
- Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease). | Cottin, V., et al. 2007. Respiration. 74: 361-78. PMID: 17641482
- Neuroimaging supports central pathology in familial dysautonomia. | Axelrod, FB., et al. 2010. J Neurol. 257: 198-206. PMID: 19705052
- Molecular characterization and mutational analysis of the human B17 subunit of the mitochondrial respiratory chain complex I. | Smeitink, J., et al. 1998. Hum Genet. 103: 245-50. PMID: 9760212
- Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. | Emahazion, T., et al. 1998. Cytogenet Cell Genet. 82: 115-9. PMID: 9763677
- The nuclear-encoded human NADH:ubiquinone oxidoreductase NDUFA8 subunit: cDNA cloning, chromosomal localization, tissue distribution, and mutation detection in complex-I-deficient patients. | Triepels, R., et al. 1998. Hum Genet. 103: 557-63. PMID: 9860297
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NDUFA8 Antibody (C-6) | sc-398097 | 200 µg/ml | $322.00 | |||
NDUFA8 Antibody (C-6): m-IgG Fc BP-HRP Bundle | sc-526287 | 200 µg Ab; 10 µg BP | $361.00 | |||
NDUFA8 Antibody (C-6): m-IgG2a BP-HRP Bundle | sc-546562 | 200 µg Ab; 10 µg BP | $361.00 | |||
NDUFA8 Antibody (C-6) AC | sc-398097 AC | 500 µg/ml, 25% agarose | $424.00 | |||
NDUFA8 Antibody (C-6) HRP | sc-398097 HRP | 200 µg/ml | $322.00 | |||
NDUFA8 Antibody (C-6) FITC | sc-398097 FITC | 200 µg/ml | $336.00 | |||
NDUFA8 Antibody (C-6) PE | sc-398097 PE | 200 µg/ml | $349.00 | |||
NDUFA8 Antibody (C-6) Alexa Fluor® 488 | sc-398097 AF488 | 200 µg/ml | $364.00 | |||
NDUFA8 Antibody (C-6) Alexa Fluor® 546 | sc-398097 AF546 | 200 µg/ml | $364.00 | |||
NDUFA8 Antibody (C-6) Alexa Fluor® 594 | sc-398097 AF594 | 200 µg/ml | $364.00 | |||
NDUFA8 Antibody (C-6) Alexa Fluor® 647 | sc-398097 AF647 | 200 µg/ml | $364.00 | |||
NDUFA8 Antibody (C-6) Alexa Fluor® 680 | sc-398097 AF680 | 200 µg/ml | $364.00 | |||
NDUFA8 Antibody (C-6) Alexa Fluor® 790 | sc-398097 AF790 | 200 µg/ml | $364.00 |