NDRG1 Antibody (S-7): sc-100786
- NDRG1 Antibody (S-7) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 100 µg/ml
- raised against recombinant NDRG1 of human origin
- recommended for detection of NDRG1 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NDRG1 Antibody (S-7). This work is in progress.
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NDRG1 Antibody (S-7) is a mouse monoclonal IgG2a antibody that detects NDRG1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). NDRG1, a member of the N-myc downstream regulated gene family, plays a crucial role in cellular stress responses, hormone signaling, and the regulation of cell growth and differentiation, making NDRG1 vital for maintaining cellular homeostasis and responding to environmental changes. NDRG1 is predominantly expressed in placental membranes, as well as in the prostate, kidney, small intestine, and ovary, highlighting NDRG1′s importance in reproductive and developmental processes. NDRG1 expression is notably induced by various stimuli, including nickel, which suggests NDRG1′s involvement in adaptive responses to stressors. Additionally, NDRG1 interacts with several key proteins, including p53 and HIF-1α, which are critical for tumor suppression and cellular oxygen sensing, respectively. NDRG1′s ability to modulate these interactions underscores NDRG1′s potential as a biomarker for cancer progression and a target for therapeutic intervention.
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NDRG1 Antibody (S-7) References:
- The Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity. | Chekmarev, J., et al. 2021. Cells. 10: PMID: 34572031
- NDRG1 Signaling Is Essential for Endothelial Inflammation and Vascular Remodeling. | Zhang, G., et al. 2023. Circ Res. 132: 306-319. PMID: 36562299
- The role of the NDRG1 in the pathogenesis and treatment of breast cancer. | Zhao, X. and Richardson, DR. 2023. Biochim Biophys Acta Rev Cancer. 1878: 188871. PMID: 36841367
- CRISPR/Cas9 Screen in Gastric Cancer Patient-Derived Organoids Reveals KDM1A-NDRG1 Axis as a Targetable Vulnerability. | Mircetic, J., et al. 2023. Small Methods. 7: e2201605. PMID: 36908010
- NDRG1 facilitates self-renewal of liver cancer stem cells by preventing EpCAM ubiquitination. | Cheng, Q., et al. 2023. Br J Cancer. 129: 237-248. PMID: 37165202
- NDRG1 promotes endothelial dysfunction and hypoxia-induced pulmonary hypertension by targeting TAF15. | Li, C., et al. 2023. Precis Clin Med. 6: pbad024. PMID: 37885911
- NDRG1 overcomes resistance to immunotherapy of pancreatic ductal adenocarcinoma through inhibiting ATG9A-dependent degradation of MHC-1. | Zhang, Z., et al. 2024. Drug Resist Updat. 73: 101040. PMID: 38228036
- NSUN6-mediated 5-methylcytosine modification of NDRG1 mRNA promotes radioresistance in cervical cancer. | Yu, M., et al. 2024. Mol Cancer. 23: 139. PMID: 38970106
- NDRG1 enhances the sensitivity to Cetuximab by promoting Stat1 ubiquitylation in colorectal cancer. | Yang, G., et al. 2024. J Adv Res.. PMID: 39128702
- NDRG1 Regulates Iron Metabolism and Inhibits Pathologic Cardiac Hypertrophy. | Yuan, J., et al. 2025. Can J Cardiol. 41: 224-240. PMID: 39427843
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NDRG1 Antibody (S-7) | sc-100786 | 100 µg/ml | $339.00 |