NDRG1 Antibody (B-5): sc-398291

NDRG1 Antibody (B-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects NDRG1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-NDRG1 antibody (B-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NDRG1, part of the N-myc downstream regulated gene family, plays a crucial role in cellular stress responses, hormone signaling, and cell growth and differentiation, making NDRG1 vital for maintaining cellular homeostasis and responding to environmental changes. NDRG1 is predominantly expressed in tissues such as placenta, prostate, kidney, small intestine, and ovary, indicating NDRG1′s importance in reproductive and developmental processes. Additionally, NDRG1 is regulated by various stimuli, including nickel, which can enhance expression, further underscoring NDRG1′s role in adaptive responses to stressors. The evolutionary conservation of NDRG1 across species highlights fundamental biological significance, making NDRG1 (B-5) monoclonal antibody an essential tool for researchers studying diverse functions in health and disease.

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NDRG1 Antibody (B-5) References:

1. Phosphorylation of RTP, an ER stress-responsive cytoplasmic protein.  |  Agarwala, KL., et al. 2000. Biochem Biophys Res Commun. 272: 641-7. PMID: 10860807
2. Hypoxia induces the expression of a 43-kDa protein (PROXY-1) in normal and malignant cells.  |  Park, H., et al. 2000. Biochem Biophys Res Commun. 276: 321-8. PMID: 11006124
3. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart.  |  Zhou, RH., et al. 2001. Genomics. 73: 86-97. PMID: 11352569
4. Cloning and expression pattern of the human NDRG3 gene.  |  Zhao, W., et al. 2001. Biochim Biophys Acta. 1519: 134-8. PMID: 11406283
5. The role of NDRG1 in the pathology and potential treatment of human cancers.  |  Bae, DH., et al. 2013. J Clin Pathol. 66: 911-7. PMID: 23750037
6. NDRG1 in Aggressive Breast Cancer Progression and Brain Metastasis.  |  Villodre, ES., et al. 2022. J Natl Cancer Inst. 114: 579-591. PMID: 34893874
7. TGFβ Governs the Pleiotropic Activity of NDRG1 in Triple-Negative Breast Cancer Progression.  |  López-Tejada, A., et al. 2023. Int J Biol Sci. 19: 204-224. PMID: 36594086
8. Role of KLF4/NDRG1/DRP1 axis in hypoxia-induced pulmonary hypertension.  |  Liu, Y., et al. 2023. Biochim Biophys Acta Mol Basis Dis. 1869: 166794. PMID: 37356737
9. Overexpression of NDRG1 leads to poor prognosis in hepatocellular carcinoma through mediating immune infiltration and EMT.  |  Wang, X., et al. 2024. Dig Liver Dis. 56: 1382-1399. PMID: 38290958
10. A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms.  |  van Belzen, N., et al. 1997. Lab Invest. 77: 85-92. PMID: 9251681
11. Cap43, a novel gene specifically induced by Ni2+ compounds.  |  Zhou, D., et al. 1998. Cancer Res. 58: 2182-9. PMID: 9605764
12. Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage.  |  Kurdistani, SK., et al. 1998. Cancer Res. 58: 4439-44. PMID: 9766676

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NDRG1 Antibody (B-5) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-NDRG1 Antibody (B-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NDRG1 Antibody (B-5) Specifications

Alternate Product Name: NDRG1

Product Clone Name: B-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2-29

Epitope Target: NDRG1

Epitope Species: human

Product Reactivity/Detection: NDRG1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for NDRG1 Antibody (B-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin