NDOR1 Antibody (XX-9): sc-100482

NDOR1 Antibody (XX-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects NDOR1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-NDOR1 antibody (XX-9) is available as a non-conjugated monoclonal isotype antibody. NDOR1, also known as NADPH-dependent diflavin oxidoreductase 1 or NR1 (Novel reductase 1), is a 597 amino acid cytoplasmic protein characterized by the presence of one FAD-binding domain and one flavodoxin-like domain. NDOR1 is expressed at low levels in various tissues, including heart, brain, kidney, pancreas, prostate, and skeletal muscle, but is particularly abundant in placenta. NDOR1 plays a crucial role as an oxidoreductase, utilizing FAD and FMN as cofactors to facilitate NADP-dependent reduction of one-electron acceptors such as cytochrome c, menadione, and potassium ferricyanide. This enzymatic activity is vital for cellular redox balance and energy metabolism. NDOR1 is implicated in tumorigenesis, showing presence in various cancer cell lines, including lung carcinoma, melanoma G361, promyelocytic leukemia, HeLa S3, chronic myelogenous leukemia, lymphoblastic leukemia, Burkitt′s lymphoma, and colorectal adenocarcinoma. Two isoforms of NDOR1 arise from alternative splicing events, contributing to functional diversity and regulatory mechanisms in different cellular contexts.

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NDOR1 Antibody (XX-9) References:

1. Cloning and characterization of a novel human dual flavin reductase.  |  Paine, MJ., et al. 2000. J Biol Chem. 275: 1471-8. PMID: 10625700
2. Redundancy in the pathway for redox regulation of mammalian methionine synthase: reductive activation by the dual flavoprotein, novel reductase 1.  |  Olteanu, H. and Banerjee, R. 2003. J Biol Chem. 278: 38310-4. PMID: 12871938
3. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1.  |  Kwasnicka, DA., et al. 2003. J Biol Chem. 278: 39051-8. PMID: 12871939
4. Identification of a functionally impaired allele of human novel oxidoreductase 1 (NDOR1), NDOR1*1.  |  Finn, RD., et al. 2005. Pharmacogenet Genomics. 15: 381-6. PMID: 15900210
5. Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity.  |  Kwaśnicka-Crawford, DA. and Vincent, SR. 2005. Biochem Biophys Res Commun. 336: 565-71. PMID: 16140270
6. Reduction of NR1 and phosphorylated Ca2+/calmodulin-dependent protein kinase II levels in Alzheimer's disease.  |  Amada, N., et al. 2005. Neuroreport. 16: 1809-13. PMID: 16237332
7. Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis.  |  Netz, DJ., et al. 2010. Nat Chem Biol. 6: 758-65. PMID: 20802492
8. Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis.  |  Banci, L., et al. 2013. Proc Natl Acad Sci U S A. 110: 7136-41. PMID: 23596212
9. Iodine-131 dose-dependent gene expression: alterations in both normal and tumour thyroid tissues of post-Chernobyl thyroid cancers.  |  Abend, M., et al. 2013. Br J Cancer. 109: 2286-94. PMID: 24045656
10. Identification of one-electron reductases that activate both the hypoxia prodrug SN30000 and diagnostic probe EF5.  |  Wang, J., et al. 2014. Biochem Pharmacol. 91: 436-46. PMID: 25130546
11. Anamorsin/Ndor1 Complex Reduces [2Fe-2S]-MitoNEET via a Transient Protein-Protein Interaction.  |  Camponeschi, F., et al. 2017. J Am Chem Soc. 139: 9479-9482. PMID: 28648056
12. The expression of cuproptosis-related genes in hepatocellular carcinoma and their relationships with prognosis.  |  Zhao, X., et al. 2022. Front Oncol. 12: 992468. PMID: 36313717

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NDOR1 Antibody (XX-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-NDOR1 Antibody (XX-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NDOR1 Antibody (XX-9) Specifications

Alternate Product Name: NDOR1

Product Clone Name: XX-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 498-596

Epitope Target: NDOR1

Epitope Species: human

Product Reactivity/Detection: NDOR1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 50 µg IgG_2a kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for NDOR1 Antibody (XX-9): N/A