NCS-1 Antibody (1): sc-136000
- NCS-1 Antibody (1) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 1-190 representing full length NCS-1 of rat origin
- recommended for detection of NCS-1 of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NCS-1 Antibody (1). This work is in progress.
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NCS-1 Antibody (1) is a mouse monoclonal IgG1 antibody that detects NCS-1 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). NCS-1, also known as neuronal calcium sensor-1 or frequenin, is a crucial regulatory protein that plays a significant role in calcium-dependent exocytosis, particularly in the release of neurotransmitters from synaptic vesicles and dense core granules. NCS-1 is primarily localized in neuronal cell bodies and axons throughout the brain and spinal cord, as well as in glial cells and neuroendocrine cells, such as bovine adrenal chromaffin and PC12 cells. The proper functioning of NCS-1 is vital for maintaining synaptic transmission and neuronal communication, as NCS-1 helps modulate calcium signaling pathways that are essential for various cellular processes. Additionally, NCS-1 is involved in a voltage-independent autocrine pathway that negatively regulates non-L-type calcium channels, further underscoring its importance in neuronal excitability and signaling. Anti-NCS-1 antibody (1) is an invaluable tool for researchers studying calcium signaling and its implications in neurobiology.
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NCS-1 Antibody (1) References:
- Multiple roles for frequenin/NCS-1 in synaptic function and development. | Dason, JS., et al. 2012. Mol Neurobiol. 45: 388-402. PMID: 22396213
- TRPC5. | Zholos, AV. 2014. Handb Exp Pharmacol. 222: 129-56. PMID: 24756705
- Calcium Sensor, NCS-1, Promotes Tumor Aggressiveness and Predicts Patient Survival. | Moore, LM., et al. 2017. Mol Cancer Res. 15: 942-952. PMID: 28275088
- NCS-1 is a regulator of calcium signaling in health and disease. | Boeckel, GR. and Ehrlich, BE. 2018. Biochim Biophys Acta Mol Cell Res. 1865: 1660-1667. PMID: 29746899
- NCS-1 Deficiency Is Associated With Obesity and Diabetes Type 2 in Mice. | Ratai, O., et al. 2019. Front Mol Neurosci. 12: 78. PMID: 31001084
- NCS-1 expression is higher in basal breast cancers and regulates calcium influx and cytotoxic responses to doxorubicin. | Bong, AHL., et al. 2020. Mol Oncol. 14: 87-104. PMID: 31647602
- Contribution of neuronal calcium sensor 1 (Ncs-1) to anxiolytic-like and social behavior mediated by valproate and Gsk3 inhibition. | Magno, LAV., et al. 2020. Sci Rep. 10: 4566. PMID: 32165725
- The inhibition of NCS-1 binding to Ric8a rescues fragile X syndrome mice model phenotypes. | Cogram, P., et al. 2022. Front Neurosci. 16: 1007531. PMID: 36466176
- The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A. | Muñoz-Reyes, D., et al. 2023. Elife. 12: PMID: 38018500
- NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells. | Sánchez, JC., et al. 2024. J Physiol Biochem. 80: 451-463. PMID: 38564162
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NCS-1 Antibody (1) | sc-136000 | 50 µg/0.5 ml | $316.00 |