NCoA-3 Antibody (6D102): sc-71657
- NCoA-3 Antibody (6D102) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against amino acids 605-1294 of NCoA-3 of human origin
- recommended for detection of NCoA-3 of human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NCoA-3 Antibody (6D102). This work is in progress.
NCoA-3 Antibody (6D102) is a mouse monoclonal IgG1 antibody that detects NCoA-3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. NCoA-3, also known as RAC3, ACTR, AIB-1, and p/CIP, plays a crucial role as a transcriptional coactivator that interacts with steroid hormone receptors, thereby influencing gene expression in response to hormonal signals. NCoA-3 (6D102) antibody has proven valuable in studying elevated expression levels in estrogen receptor-positive ovarian and breast cancers, underscoring NCoA-3′s potential as a biomarker for these malignancies. NCoA-3′s ability to modulate transcriptional activity through interactions with various nuclear receptors and other coactivators makes NCoA-3 a vital component in the regulation of hormone-responsive genes, highlighting NCoA-3′s importance in both normal physiology and disease states. Anti-NCoA-3 antibody (6D102) serves as an essential tool for researchers investigating the mechanisms of hormone action and the role of coactivators in cancer progression.
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NCoA-3 Antibody (6D102) References:
- Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling. | Hajdo-Milasinovic, A., et al. 2009. J Cell Sci. 122: 2127-36. PMID: 19494130
- Roles of Rac1 and Rac3 GTPases during the development of cortical and hippocampal GABAergic interneurons. | de Curtis, I. 2014. Front Cell Neurosci. 8: 307. PMID: 25309333
- miR-17-5p Regulates Differential Expression of NCOA3 in Pig Intramuscular and Subcutaneous Adipose Tissue. | Han, H., et al. 2017. Lipids. 52: 939-949. PMID: 28921416
- Rac3, but not Rac1, promotes ox-LDL induced endothelial dysfunction by downregulating autophagy. | He, D., et al. 2020. J Cell Physiol. 235: 1531-1542. PMID: 31332791
- NR5A2 synergizes with NCOA3 to induce breast cancer resistance to BET inhibitor by upregulating NRF2 to attenuate ferroptosis. | Qiao, J., et al. 2020. Biochem Biophys Res Commun. 530: 402-409. PMID: 32536370
- RAC3 Promotes Proliferation, Migration and Invasion via PYCR1/JAK/STAT Signaling in Bladder Cancer. | Cheng, C., et al. 2020. Front Mol Biosci. 7: 218. PMID: 33062641
- Rac1 and Rac3 have opposite functions in Schwann cells during developmental myelination. | Pellegatta, M., et al. 2021. Neurosci Lett. 753: 135868. PMID: 33812927
- Dispensable role of Rac1 and Rac3 after cochlear hair cell specification. | Nakamura, T., et al. 2023. J Mol Med (Berl). 101: 843-854. PMID: 37204479
- Integrated analysis identifies RAC3 as an immune-related prognostic biomarker associated with chemotherapy sensitivity in endometrial cancer. | Huang, P., et al. 2023. J Cell Mol Med. 27: 2385-2397. PMID: 37386813
- NCOA3 knockdown delays human embryo development. | Wu, Z., et al. 2024. Heliyon. 10: e37639. PMID: 39315150
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NCoA-3 Antibody (6D102) | sc-71657 | 200 µg/ml | $322.00 |