NCK1 Antibody (108): sc-136232
- NCK1 Antibody (108) is a mouse monoclonal mouse IgG2b κ κ provided at 50 µg/0.5 ml
- raised against amino acids 279-377 of NCK1 of human origin
- recommended for detection of NCK1 of mouse, rat, human, bovine and canine origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NCK1 Antibody (108). This work is in progress.
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NCK1 Antibody (108) is a mouse monoclonal IgG2b antibody that detects NCK1 in mouse, rat, human, bovine, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). NCK1, a member of the NCK family of SH2/SH3 adaptor proteins, plays a crucial role in mediating tyrosine kinase signaling pathways, including those activated by epidermal growth factor (EGF) and platelet-derived growth factor (PDGF). NCK1 is primarily located in the cytoplasm, where NCK1 facilitates the interaction between various signaling molecules, thereby influencing cellular processes such as growth, differentiation, and cytoskeletal dynamics. NCK1′s cellular location enables rapid responses to extracellular signals, allowing for timely modulation of downstream signaling cascades. NCK1 interacts with p21-activated kinase (PAK), a key regulator of the actin cytoskeleton, which underscores NCK1′s role in coordinating cellular responses to growth factors. The human NCK1 gene is located on chromosome 3q22.3, and NCK1 expression is tightly regulated, as overexpression can lead to altered cellular behaviors, such as decreased DNA synthesis in response to EGF stimulation. With versatile applications and critical involvement in signaling pathways, anti-NCK1 antibody (108) serves as an essential tool for researchers studying cellular signaling and its implications in various biological processes.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NCK1 Antibody (108) References:
- NCK1 promotes the angiogenesis of cervical squamous carcinoma via Rac1/PAK1/MMP2 signal pathway. | Xia, P., et al. 2019. Gynecol Oncol. 152: 387-395. PMID: 30442385
- NCK1-AS1 promotes NCK1 expression to facilitate tumorigenesis and chemo-resistance in ovarian cancer. | Chang, H., et al. 2020. Biochem Biophys Res Commun. 522: 292-299. PMID: 31761329
- Nck1 promotes the progression of ovarian carcinoma by enhancing the PI3K/AKT/p70S6K signaling. | Liu, X., et al. 2020. Hum Cell. 33: 768-779. PMID: 32166565
- Selective role of Nck1 in atherogenic inflammation and plaque formation. | Alfaidi, M., et al. 2020. J Clin Invest. 130: 4331-4347. PMID: 32427580
- NCK1-AS1 promotes the progression of melanoma by accelerating cell proliferation and migration via targeting miR-526b-5p/ADAM15 axis. | Lin, Q., et al. 2021. Cancer Cell Int. 21: 367. PMID: 34247598
- STAT3-induced NCK1 elevation promotes migration of triple-negative breast cancer cells via regulating ERK1/2 signaling. | He, P., et al. 2022. Mol Biol Rep. 49: 267-278. PMID: 34846647
- Knockdown of NCK1-AS1 inhibits the development of atherosclerosis by targeting miR-1197/COX10 axis. | Zhang, B., et al. 2022. J Biol Eng. 16: 2. PMID: 34986861
- LncRNA NCK1-AS1 Aggravates Hepatocellular Carcinoma by the miR-22-3p/YARS Axis to Activate PI3K/AKT Signaling. | Zhou, W., et al. 2022. J Gastrointestin Liver Dis. 31: 48-59. PMID: 35306563
- Long non-coding RNA NCK1-AS1 is overexpressed in esophageal squamous cell carcinoma and predicts survival. | Fu, X., et al. 2022. Bioengineered. 13: 8302-8310. PMID: 35311444
- Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development. | Golding, AP., et al. 2023. J Mammary Gland Biol Neoplasia. 28: 19. PMID: 37479911
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NCK1 Antibody (108) | sc-136232 | 50 µg/0.5 ml | $322.00 |