Molecular structure of NBQX disodium salt, CAS Number: 479347-86-9
NBQX disodium salt (CAS 479347-86-9)
See product citations (5)
Alternate Names:
NBQX disodium salt is known as a AMPA/kainate antagonist.
Application:
NBQX disodium salt is a selective and potent AMPA- and kainate-sensitive glutamate receptor antagonist.
CAS Number:
479347-86-9
Purity:
≥98%
Molecular Weight:
380.24
Molecular Formula:
C12H6N4O6S•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NBQX disodium salt is a water soluble, selective, and competitive AMPA/kainate receptor antagonist. Highly potent, NBQX disodium salt works against AMPA and kainate receptors at micromolar concentrations. NBQX disodium salt serves as a neuroprotective agent and anticonvulsant. In vivo, NBQX disodium salt has proven to be active. Kinetic studies involving N-methyl-D-aspartate receptors have used NBQX disodium salt. NBQX disodium salt is analogous to the quinoxalinedione antagonists to the non-NMDA glutamate receptor. In rat neocortex slices, NBQX disodium salt was reported to block excitatory actions.
NBQX disodium salt (CAS 479347-86-9) References
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- TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation. | Lappin, SC., et al. 2006. Eur J Pharmacol. 540: 73-81. PMID: 16737693
- Theanine, gamma-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats. | Yamada, T., et al. 2009. Amino Acids. 36: 21-7. PMID: 18196445
- SAP102 is a highly mobile MAGUK in spines. | Zheng, CY., et al. 2010. J Neurosci. 30: 4757-66. PMID: 20357126
- Electrophysiological analysis of the modulation of NMDA-receptors function by D-serine and glycine in the central nervous system. | Turpin, F., et al. 2012. Methods Mol Biol. 794: 299-312. PMID: 21956572
- GluN2B antagonism affects interneurons and leads to immediate and persistent changes in synaptic plasticity, oscillations, and behavior. | Hanson, JE., et al. 2013. Neuropsychopharmacology. 38: 1221-33. PMID: 23340518
- NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex. | Wang, M., et al. 2013. Neuron. 77: 736-49. PMID: 23439125
- Roles of the spinal glutamatergic pathway activated through α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors and its interactions with spinal noradrenergic and serotonergic pathways in the rat urethral continence mechanisms. | Kawamorita, N., et al. 2015. Neurourol Urodyn. 34: 475-81. PMID: 24668912
- Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity. | Eckel, R., et al. 2015. Neuropharmacology. 88: 82-90. PMID: 25245802
- Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus. | Hernández, VM., et al. 2015. J Neurosci. 35: 11830-47. PMID: 26311767
- TrkB-dependent disinhibition of the nucleus accumbens is enhanced by ethanol. | Patton, MH., et al. 2019. Neuropsychopharmacology. 44: 1114-1122. PMID: 30758322
- The Novel Direct Modulatory Effects of Perampanel, an Antagonist of AMPA Receptors, on Voltage-Gated Sodium and M-type Potassium Currents. | Lai, MC., et al. 2019. Biomolecules. 9: PMID: 31652643
- The selective dopamine D1 receptor agonist SKF81297 modulates NMDA receptor currents independently of D1 receptors. | Nesbit, MO., et al. 2022. Neuropharmacology. 207: 108967. PMID: 35077763
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GluR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NBQX disodium salt, 5 mg | sc-222048 | 5 mg | $113.00 | |||
NBQX disodium salt, 25 mg | sc-222048A | 25 mg | $420.00 |