NAT-10 Antibody (D-11): sc-271771
- NAT-10 Antibody (D-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 726-1025 mapping at the C-terminus of NAT-10 of human origin
- recommended for detection of NAT-10 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG1 BP-HRP is the preferred secondary detection reagent for NAT-10 Antibody (D-11) for WB and IHC(P) applications. This reagent is now offered in a bundle with NAT-10 Antibody (D-11) (see ordering information below).
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NAT-10 Antibody (D-11) is a mouse monoclonal IgG1 antibody that detects NAT-10 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). NAT-10, or N-acetyltransferase 10, is a crucial nuclear protein that plays a significant role in the regulation of telomerase activity, which is vital for maintaining telomere length and genomic stability. NAT-10 is characterized by a single N-acetyltransferase domain, which is believed to function as a histone acetyltransferase, thereby influencing chromatin structure and gene expression. NAT-10 is upregulated in response to DNA damage, highlighting NAT-10′s importance in genotoxic resistance and DNA repair mechanisms. High binding affinity for the promoter region of the telomerase reverse transcriptase (TERT) gene underscores NAT-10′s role in stimulating telomerase production, suggesting that human telomerase complexes may have diverse functions beyond their traditional roles. NAT-10′s versatility in cellular processes makes NAT-10 a critical target for research in cancer biology and aging, where telomere maintenance is a key factor.
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NAT-10 Antibody (D-11) References:
- PIWI-Interacting RNA HAAPIR Regulates Cardiomyocyte Death After Myocardial Infarction by Promoting NAT10-Mediated ac4 C Acetylation of Tfec mRNA. | Wang, K., et al. 2022. Adv Sci (Weinh). 9: e2106058. PMID: 35138696
- Targeting NAT10 protects against sepsis-induced skeletal muscle atrophy by inhibiting ROS/NLRP3. | Wang, C., et al. 2023. Life Sci. 330: 121948. PMID: 37467885
- NAT10-mediated RNA acetylation enhances HNRNPUL1 mRNA stability to contribute cervical cancer progression. | Long, Y., et al. 2023. Int J Med Sci. 20: 1079-1090. PMID: 37484809
- CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression. | Shuai, Y., et al. 2024. Cell Death Dis. 15: 9. PMID: 38182571
- RNPS1 stabilizes NAT10 protein to facilitate translation in cancer via tRNA ac4C modification. | Wang, X., et al. 2024. Int J Oral Sci. 16: 6. PMID: 38246918
- Molecular Basis for RNA Cytidine Acetylation by NAT10. | Zhou, M., et al. 2024. bioRxiv.. PMID: 38585770
- NAT10 inhibition promotes ac4C-dependent ferroptosis to counteract sorafenib resistance in nasopharyngeal carcinoma. | Xue, Z., et al. 2024. Cancer Sci. 115: 3256-3272. PMID: 39038928
- m6A-driven NAT10 translation facilitates fatty acid metabolic rewiring to suppress ferroptosis and promote ovarian tumorigenesis through enhancing ACOT7 mRNA acetylation. | Liu, Y., et al. 2024. Oncogene. 43: 3498-3516. PMID: 39390256
- The role and mechanism of NAT10-mediated ac4C modification in tumor development and progression. | Gu, Z., et al. 2024. MedComm (2020). 5: e70026. PMID: 39640362
- NAT10 Promotes Gastric Cancer Liver Metastasis by Modulation of M2 Macrophage Polarization and Metastatic Tumor Cell Hepatic Adhesion. | Chen, C., et al. 2025. Adv Sci (Weinh). e2410263. PMID: 39985269
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NAT-10 Antibody (D-11) | sc-271771 | 200 µg/ml | $322.00 | |||
NAT-10 Antibody (D-11): m-IgG1 BP-HRP Bundle | sc-542681 | 200 µg Ab; 20 µg BP | $361.00 |