NAT-1/2 Antibody (H-7): sc-271797
- NAT-1/2 Antibody (H-7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 117-168 mapping within an internal region of NAT-1 of human origin
- recommended for detection of NAT-1 and NAT-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for NAT-1/2 Antibody (H-7) for WB and IHC(P) applications. These reagents are now offered in bundles with NAT-1/2 Antibody (H-7) (see ordering information below).
NAT-1/2 Antibody (H-7) is a mouse monoclonal IgG1 antibody that detects Arylamine N-acetyltransferase-1/2 (NAT-1/2) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). NAT-1/2 plays a crucial role in the detoxification process by catalyzing the N- or O-acetylation of heterocyclic and arylamine substrates, which is essential for the metabolism of a wide range of drugs and environmental toxins. The importance of NAT-1/2 is underscored by its involvement in the bioactivation of several known carcinogens, linking certain alleles of NAT-1 and NAT-2 to increased susceptibility to colon and urinary bladder cancers. Both NAT-1 and NAT-2 are located in the cytoplasm, where these proteins actively participate in detoxifying arylamine and hydrazine drugs, thereby influencing drug efficacy and toxicity. The polymorphism in N-acetylation is determined by NAT activity levels in liver tissues, which can significantly affect the pharmacokinetics of drugs containing amines. Notably, human NAT-1 serves as the functional homolog of rodent NAT-2, while human NAT-2 corresponds to rodent NAT-1, highlighting the evolutionary conservation and functional significance of these enzymes across species. NAT-1/2 (H-7) antibody is an invaluable tool for researchers studying drug metabolism, cancer biology, and the genetic factors influencing drug response.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NAT-1/2 Antibody (H-7) | sc-271797 | 200 µg/ml | $316.00 | |||
NAT-1/2 Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-537695 | 200 µg Ab; 10 µg BP | $354.00 | |||
NAT-1/2 Antibody (H-7): m-IgGκ BP-HRP Bundle | sc-535043 | 200 µg Ab; 40 µg BP | $354.00 | |||
NAT-1/2 Antibody (H-7): m-IgG1 BP-HRP Bundle | sc-545313 | 200 µg Ab; 20 µg BP | $354.00 |