NAP-2 Antibody (3H428): sc-71642

NAP-2 Antibody (3H428) is a mouse monoclonal IgG1 antibody that detects NAP-2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-NAP-2 antibody (3H428) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. NAP-2, also known as neutrophil-activating peptide 2, plays a crucial role in the immune response by mediating chemotaxis and degranulation in neutrophils, which are essential processes during inflammation. NAP-2 is derived from platelet basic protein (PBP), a member of the α-chemokine family, which is stored in the α-granules of platelets and released upon activation. Upon proteolytic cleavage of PBP, several biologically active peptides are generated, including NAP-2, which is vital for recruiting neutrophils to sites of injury or infection. The gene encoding human PBP is located on chromosome 4q13.3, and understanding NAP-2 function is important for elucidating its role in inflammatory diseases and potential therapeutic interventions. NAP-2 (3H428) antibody is an invaluable resource for researchers investigating the mechanisms of inflammation and the therapeutic potential of targeting chemokines in various diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

NAP-2 Antibody (3H428) References:

1. Down-regulation of neutrophil functions by the ELR(+) CXC chemokine platelet basic protein.  |  Ehlert, JE., et al. 2000. Blood. 96: 2965-72. PMID: 11049972
2. Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12-q13 along with other genes of the beta-thromboglobulin superfamily.  |  Wenger, RH., et al. 1991. Hum Genet. 87: 367-8. PMID: 1830861
3. Formation of neutrophil-activating peptide 2 from platelet-derived connective-tissue-activating peptide III by different tissue proteinases.  |  Car, BD., et al. 1991. Biochem J. 275 (Pt 3): 581-4. PMID: 2039437
4. Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin.  |  Holt, JC., et al. 1986. Biochemistry. 25: 1988-96. PMID: 2423119
5. CXC chemokines connective tissue activating peptide-III and neutrophil activating peptide-2 are heparin/heparan sulfate-degrading enzymes.  |  Hoogewerf, AJ., et al. 1995. J Biol Chem. 270: 3268-77. PMID: 7852412
6. The amino-terminal residues in the crystal structure of connective tissue activating peptide-III (des10) block the ELR chemotactic sequence.  |  Malkowski, MG., et al. 1997. J Mol Biol. 266: 367-80. PMID: 9047370
7. Structure and bioactivity of recombinant human CTAP-III and NAP-2.  |  Proudfoot, AE., et al. 1997. J Protein Chem. 16: 37-49. PMID: 9055206

The preferred PBP antibody is PBP Antibody (C-24): sc-73636.