NALP14 Antibody (H-10): sc-398068
- NALP14 Antibody (H-10) is a mouse monoclonal IgG1 κ NALP14 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 108-153 within an internal region of NALP14 of human origin
- NALP14 Antibody (H-10) is recommended for detection of NALP14 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-NALP14 Antibody (H-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for NALP14 Antibody (H-10) for WB applications. These reagents are now offered in bundles with NALP14 Antibody (H-10) (see ordering information below).
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NALP14 Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects NALP14 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NALP14 (H-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NALP14, also known as NACHT, LRR and PYD domains-containing protein 14, is a testis-specific nucleotide-binding protein that plays a crucial role in immune response. NALP14 is a member of the NLRP family and features a unique structure comprising one DAPIN domain, eleven leucine-rich repeats, and one NACHT domain, which are essential for function as an intracellular receptor involved in innate immunity. NALP14 has been implicated in spermatogenesis and functions as a component of the inflammasome, a multi-protein complex that activates inflammatory responses. The inflammasome forms through assembly of a NALP member and an ASC adapter, which is critical for recruiting caspase-1, an enzyme that processes pro-inflammatory cytokines. NALP14′s ability to interact with various microbial, foreign, and endogenous stimuli highlights its importance in maintaining immune homeostasis and responding to cellular stress.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NALP14 Antibody (H-10) References:
- NALPs: a novel protein family involved in inflammation. | Tschopp, J., et al. 2003. Nat Rev Mol Cell Biol. 4: 95-104. PMID: 12563287
- Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. | Chamaillard, M., et al. 2003. Cell Microbiol. 5: 581-92. PMID: 12925128
- The mouse germ-cell-specific leucine-rich repeat protein NALP14: a member of the NACHT nucleoside triphosphatase family. | Horikawa, M., et al. 2005. Biol Reprod. 72: 879-89. PMID: 15590904
- NACHT-LRR proteins (NLRs) in bacterial infection and immunity. | Kufer, TA., et al. 2005. Trends Microbiol. 13: 381-8. PMID: 15994078
- Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure. | Westerveld, GH., et al. 2006. Hum Reprod. 21: 3178-84. PMID: 16931801
- NALP inflammasomes: a central role in innate immunity. | Martinon, F., et al. 2007. Semin Immunopathol. 29: 213-29. PMID: 17703304
- The inflammasome, autoinflammatory diseases, and gout. | Pétrilli, V. and Martinon, F. 2007. Joint Bone Spine. 74: 571-6. PMID: 17714972
- Orchestration of pathogen recognition by inflammasome diversity: Variations on a common theme. | Martinon, F. 2007. Eur J Immunol. 37: 3003-6. PMID: 17960661
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NALP14 Antibody (H-10) | sc-398068 | 200 µg/ml | $322.00 | |||
NALP14 Antibody (H-10): m-IgG Fc BP-HRP Bundle | sc-527733 | 200 µg Ab; 10 µg BP | $361.00 | |||
NALP14 Antibody (H-10): m-IgG1 BP-HRP Bundle | sc-533106 | 200 µg Ab; 20 µg BP | $361.00 | |||
NALP14 Antibody (H-10) AC | sc-398068 AC | 500 µg/ml, 25% agarose | $424.00 | |||
NALP14 Antibody (H-10) HRP | sc-398068 HRP | 200 µg/ml | $322.00 | |||
NALP14 Antibody (H-10) FITC | sc-398068 FITC | 200 µg/ml | $336.00 | |||
NALP14 Antibody (H-10) PE | sc-398068 PE | 200 µg/ml | $349.00 | |||
NALP14 Antibody (H-10) Alexa Fluor® 488 | sc-398068 AF488 | 200 µg/ml | $364.00 | |||
NALP14 Antibody (H-10) Alexa Fluor® 546 | sc-398068 AF546 | 200 µg/ml | $364.00 | |||
NALP14 Antibody (H-10) Alexa Fluor® 594 | sc-398068 AF594 | 200 µg/ml | $364.00 | |||
NALP14 Antibody (H-10) Alexa Fluor® 647 | sc-398068 AF647 | 200 µg/ml | $364.00 | |||
NALP14 Antibody (H-10) Alexa Fluor® 680 | sc-398068 AF680 | 200 µg/ml | $364.00 | |||
NALP14 Antibody (H-10) Alexa Fluor® 790 | sc-398068 AF790 | 200 µg/ml | $364.00 | |||
NALP14 (H-10) Neutralizing Peptide | sc-398068 P | 100 µg/0.5 ml | $69.00 |