NALP1 Antibody (Nalpy1-4): sc-58550
- NALP1 Antibody (Nalpy1-4) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against full length NALP1 of human origin
- recommended for detection of NALP1 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NALP1 Antibody (Nalpy1-4). This work is in progress.
QUICK LINKS
NALP1 Antibody (Nalpy1-4) is a mouse monoclonal IgG1 antibody that detects NALP1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). NALP1, also known as caspase recruitment domain protein 7, plays a crucial role in the innate immune response as a key component of the inflammasome, which is essential for the activation of inflammatory processes. NALP1 is primarily located in the cytoplasm and is involved in forming cytoplasmic structures known as death effector filaments, which facilitate the recruitment of caspases, thereby promoting apoptosis. NALP1 expression in immune cells such as thymocytes, splenocytes, and peripheral blood leukocytes underscores its importance in regulating immune responses and maintaining homeostasis. Additionally, NALP1 contains a putative nucleotide binding site and regions rich in leucine repeats, which are critical for protein-protein interactions, enhancing NALP1′s ability to activate pro-caspase-9 in conjunction with APAF1 and cytochrome c. Anti-NALP1 antibody (Nalpy1-4) is an invaluable tool for researchers studying apoptosis, inflammation, and immune system dynamics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NALP1 Antibody (Nalpy1-4) References:
- NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. | Hiller, S., et al. 2003. Structure. 11: 1199-205. PMID: 14527388
- NALP1 is a transcriptional target for cAMP-response-element-binding protein (CREB) in myeloid leukaemia cells. | Sanz, C., et al. 2004. Biochem J. 384: 281-6. PMID: 15285719
- Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. | Faustin, B., et al. 2007. Mol Cell. 25: 713-24. PMID: 17349957
- Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. | Bruey, JM., et al. 2007. Cell. 129: 45-56. PMID: 17418785
- NALP1 and the inflammasomes: challenging our perception of vitiligo and vitiligo-related autoimmune disorders. | Taïeb, A. 2007. Pigment Cell Res. 20: 260-2. PMID: 17630958
- Induced expression of death domain genes NALP1 and NALP5 following neuronal injury. | Frederick Lo, C., et al. 2008. Biochem Biophys Res Commun. 366: 664-9. PMID: 18068672
- A coding polymorphism in NALP1 confers risk for autoimmune Addison's disease and type 1 diabetes. | Magitta, NF., et al. 2009. Genes Immun. 10: 120-4. PMID: 18946481
- DAC can restore expression of NALP1 to suppress tumor growth in colon cancer. | Chen, C., et al. 2015. Cell Death Dis. 6: e1602. PMID: 25611377
- Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1β via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling. | Liu, S., et al. 2016. Sci Rep. 6: 28956. PMID: 27381056
- Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib. | Chen, K., et al. 2018. J Neuroinflammation. 15: 292. PMID: 30342528
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NALP1 Antibody (Nalpy1-4) | sc-58550 | 50 µg/0.5 ml | $322.00 |