alpha 1 Sodium Potassium ATPase/ATP1A1 Antibody (6D133): sc-71637

Na+/K+-ATPase α1 Antibody (6D133) is a mouse monoclonal IgG1 kappa light chain antibody, specifically raised against the Na+/K+-ATPase α1 subunit of rat origin. Na+/K+-ATPase α1 monoclonal antibody (6D133) targets the Sodium-Potassium pump, also known as Na+/K+-ATPase, a crucial plasma membrane protein responsible for maintaining the electrochemical gradients of sodium and potassium ions across the cell membrane. Located in the plasma membrane, Na+/K+-ATPase plays an essential role in regulating cellular ion balance, which is vital for processes such as maintaining cell volume, establishing the resting membrane potential, and facilitating secondary active transport of various solutes. As a member of the P-type ATPase family, Na+/K+-ATPase hydrolyzes ATP to drive the active transport of three sodium ions out of the cell and two potassium ions into the cell, thereby sustaining essential physiological functions including nerve impulse transmission, muscle contraction, and kidney function. Anti-Na+/K+-ATPase α1 antibody (6D133) is validated for use in western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF), demonstrating broad species reactivity with Na+/K+-ATPase α1 from mouse, rat, human, and canine origins. Understanding the localization and function of Na+/K+-ATPase α1 is critical for investigating diseases such as hypertension, cardiac dysfunction, and neurological disorders, underscoring the importance of Na+/K+-ATPase α1 (6D133) antibody in both basic and clinical research applications.

The preferred alpha 1 Sodium Potassium ATPase/ATP1A1 antibody is alpha 1 Sodium Potassium ATPase/ATP1A1 Antibody (C464.6): sc-21712.