alpha 1 Sodium Potassium ATPase/ATP1A1 Antibody (C-5): sc-514661

Na+/K+-ATPase α1 Antibody (C-5) is a mouse monoclonal IgM kappa light chain antibody specifically designed to recognize Na+/K+-ATPase α1 subunit, also known as the Sodium-Potassium pump or ATP1A1, of human origin. Anti-Na+/K+-ATPase α1 antibody (C-5) targets an epitope between amino acids 54-77 near the N-terminus, facilitating precise detection in various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). The Na+/K+-ATPase α1 subunit is a vital membrane-bound enzyme located in the plasma membrane, responsible for maintaining the electrochemical gradients of sodium and potassium ions by actively transporting three Na⁺ ions out of the cell and two K⁺ ions into the cell using ATP hydrolysis. This protein interacts with several key regulatory and structural proteins, such as ankyrin, which links it to the cytoskeleton, and FXYD proteins, which modulate its activity and ion affinity. Additionally, Na+/K+-ATPase α1 interacts with Src kinase, playing a role in signal transduction pathways that influence cellular growth and differentiation. These interactions are crucial for maintaining cellular homeostasis, regulating membrane potential, and facilitating secondary active transport processes essential for various physiological functions. Na+/K+-ATPase α1 (C-5) antibody demonstrates broad reactivity with Na+/K+-ATPase α1 from mouse, rat, human, and canine origins, making it a versatile tool for researchers studying ion transport mechanisms, cellular signaling, and related pathophysiological conditions. By enabling accurate detection and analysis of interacting proteins, anti-Na+/K+-ATPase α1 antibody (C-5) supports advanced investigations into the molecular complexes and regulatory networks involving Na+/K+-ATPase α1.

The preferred alpha 1 Sodium Potassium ATPase/ATP1A1 antibody is alpha 1 Sodium Potassium ATPase/ATP1A1 Antibody (C464.6): sc-21712.