N-WASP Antibody (93-W): sc-100964

N-WASP Antibody (93-W) is a mouse monoclonal IgG2b antibody that detects N-WASP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Neural Wiskott-Aldrich syndrome protein (N-WASP) plays a crucial role in regulating the actin cytoskeleton, which is essential for various cellular processes including cell shape, motility, and division. N-WASP monoclonal antibody (93-W) is primarily expressed in neural tissues but is also found in other cell types, highlighting N-WASP′s importance in both the nervous system and immune response. Anti-N-WASP antibody (93-W) was raised against recombinant N-WASP of human origin. N-WASP is activated by Cdc42, a member of the Rho family of GTPases, and is vital for the formation of filopodia, which are slender cytoplasmic projections that facilitate cell signaling and interaction with the environment. The interaction of N-WASP with the Arp2/3 complex is particularly significant, as this enhances actin polymerization, thereby promoting dynamic reorganization of the cytoskeleton. N-WASP contains several important structural domains, including a pleckstrin homology domain that binds phosphatidyl-inositol bisphosphate, a Cdc42-binding domain, and a conserved verprolin-homology domain that is critical for actin binding. N-WASP′s ability to mediate actin dynamics is essential for processes such as immune cell activation and synaptic plasticity, making N-WASP a key player in both immune function and neural development.

The preferred N-WASP antibody is N-WASP Antibody (C-1): sc-271484.