N-type Ca⁺⁺ CP α1B Antibody (A-2): sc-377489

N-type Ca++ CP α1B Antibody (A-2) is a mouse monoclonal IgM antibody that detects N-type Ca++ CP alpha 1B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). N-type Ca++ CP α1B (A-2) antibody is available as the non-conjugated form. N-type calcium channels, which anti-N-type Ca++ CP alpha 1B antibody (A-2) targets, are primarily located in high-density presynaptic nerve terminals, playing a pivotal role in neuronal excitation-secretion coupling. These channels are essential for the rapid release of neurotransmitters, as they facilitate calcium entry into the neuron, which is a critical step in synaptic transmission. N-type Ca++ channels are involved in cardiovascular regulation through their peripheral distribution and interaction with the autonomic nervous system. The structural composition of these channels includes a pore-forming α-1 subunit, along with auxiliary α-2, δ, and β subunits, which together form a complex that is vital for their function. The α-1 subunit not only conducts N-type calcium currents but also interacts with proteins involved in synaptic vesicle docking and fusion, such as syntaxin, SNAP-25, and synaptotagmin, through specific binding sites in its intracellular loop II-III. This intricate interplay underscores the importance of N-type Ca++ channels in both neuronal communication and cardiovascular health, making N-type Ca++ CP α1B (A-2) monoclonal antibody a valuable tool for research in these areas.

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N-type Ca⁺⁺ CP α1B Antibody (A-2) References:

1. Pharmacology of N-type Ca2+ channels distributed in cardiovascular system (Review).  |  Uneyama, H., et al. 1999. Int J Mol Med. 3: 455-66. PMID: 10202175
2. Calcium transients and neurotransmitter release at an identified synapse.  |  Fossier, P., et al. 1999. Trends Neurosci. 22: 161-6. PMID: 10203853
3. Interactions of presynaptic Ca2+ channels and snare proteins in neurotransmitter release.  |  Catterall, WA. 1999. Ann N Y Acad Sci. 868: 144-59. PMID: 10414292
4. CaV2.2 and CaV2.3 (N- and R-type) Ca2+ channels in depolarization-evoked entry of Ca2+ into mouse sperm.  |  Wennemuth, G., et al. 2000. J Biol Chem. 275: 21210-7. PMID: 10791962
5. Structure and regulation of voltage-gated Ca2+ channels.  |  Catterall, WA. 2000. Annu Rev Cell Dev Biol. 16: 521-55. PMID: 11031246
6. Mapping of RGS12-Cav2.2 channel interaction.  |  Richman, RW. and Diversé-Pierluissi, MA. 2004. Methods Enzymol. 390: 224-39. PMID: 15488181
7. Presynaptic Cav2.1 and Cav2.2 differentially influence release dynamics at hippocampal excitatory synapses.  |  Scheuber, A., et al. 2004. J Neurosci. 24: 10402-9. PMID: 15548655
8. Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2.  |  Brittain, JM., et al. 2012. FEBS Lett. 586: 3813-8. PMID: 23022559
9. Voltage-dependent regulation of CaV2.2 channels by Gq-coupled receptor is facilitated by membrane-localized β subunit.  |  Keum, D., et al. 2014. J Gen Physiol. 144: 297-309. PMID: 25225550
10. 14-3-3τ promotes surface expression of Cav2.2 (α1B) Ca2+ channels.  |  Liu, F., et al. 2015. J Biol Chem. 290: 2689-98. PMID: 25516596
11. Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.  |  López Soto, EJ., et al. 2015. J Gen Physiol. 146: 205-19. PMID: 26283199
12. A next generation peripherally restricted Cavα2δ-1 ligand with inhibitory action on Cav2.2 channels and utility in neuropathic pain.  |  Kricek, F., et al. 2024. Biomed Pharmacother. 174: 116472. PMID: 38531121

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-N-type Ca⁺⁺ CP α1B Antibody (A-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-N-type Ca⁺⁺ CP α1B Antibody (A-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

N-type Ca⁺⁺ CP α1B Antibody (A-2) Specifications

Alternate Product Name: N-type Ca++ CP α1B

Product Clone Name: A-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1929-1961

Epitope Target: N-type Ca⁺⁺ CP α1B

Epitope Species: human

Product Reactivity/Detection: N-type Ca⁺⁺ CP α1B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for N-type Ca⁺⁺ CP α1B Antibody (A-2): P: Blocking Peptide

The preferred P/Q-type Ca⁺⁺ CP α1A antibody is P/Q-type Ca⁺⁺ CP α1A Antibody (C-2): sc-390004.