Molecular structure of N,N′-Bis(acryloyl)cystamine, CAS Number: 60984-57-8
N,N′-Bis(acryloyl)cystamine (CAS 60984-57-8)
Alternate Names:
2,2′-(Bisacrylamino)diethyl disulfide; BAC; Bis(2-acrylamidoethyl) disulfide
Application:
N,N′-Bis(acryloyl)cystamine is a reversible cross-linker for polyacrylamide gels
CAS Number:
60984-57-8
Molecular Weight:
260.38
Molecular Formula:
C10H16N2O2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
N,N′-Bis(acryloyl)cystamine (BAC) is used as a reversible cross-linker for polyacrylamide gels. The disulfide linkage can be broken with a suitable reducing agent. A 12:1 ratio of acrylamide:N,N′-Bis(acryloyl)cystamine is recommended for DNA purification. A one gram slice of a 4% gel will dissolve in 5 mL of 100 mM DTT, TBE solution (pH 8.3) in less than 30 min. The pH of 8.3 is optimum for rapid dissolution of the gel.
N,N′-Bis(acryloyl)cystamine (CAS 60984-57-8) References
- Poly(ethylene oxide)-b-poly(N-isopropylacrylamide) nanoparticles with cross-linked cores as drug carriers. | Zeng, Y. and Pitt, WG. 2005. J Biomater Sci Polym Ed. 16: 371-80. PMID: 15850290
- Surface plasmon resonance sensor for lysozyme based on molecularly imprinted thin films. | Matsunaga, T., et al. 2007. Anal Chim Acta. 591: 63-7. PMID: 17456425
- Reversible Inter- and Intra-Microgel Cross-Linking using Disulfides. | Gaulding, JC., et al. 2012. Macromolecules. 45: 39-45. PMID: 22287810
- Redox-triggered self-rolling robust hydrogel tubes for cell encapsulation. | Liu, L., et al. 2014. Macromol Rapid Commun. 35: 344-9. PMID: 24323575
- Preparation of biodegradable PEGylated pH/reduction dual-stimuli responsive nanohydrogels for controlled release of an anti-cancer drug. | Zhou, T., et al. 2015. Nanoscale. 7: 12051-60. PMID: 26118938
- Surface Charge Convertible and Biodegradable Synthetic Zwitterionic Nanoparticles for Enhancing Cellular Drug Uptake. | Wu, L., et al. 2016. Macromol Biosci. 16: 308-13. PMID: 26618931
- Nanohydrogel with N,N'-bis(acryloyl)cystine crosslinker for high drug loading. | Mackiewicz, M., et al. 2017. Int J Pharm. 523: 336-342. PMID: 28323099
- Charge reversible and biodegradable nanocarriers showing dual pH-/reduction-sensitive disintegration for rapid site-specific drug delivery. | Miao, Y., et al. 2018. Colloids Surf B Biointerfaces. 169: 313-320. PMID: 29800906
- Versatile Redox-Responsive Polyplexes for the Delivery of Plasmid DNA, Messenger RNA, and CRISPR-Cas9 Genome-Editing Machinery. | Wang, Y., et al. 2018. ACS Appl Mater Interfaces. 10: 31915-31927. PMID: 30222305
- A degradable triple temperature-, pH-, and redox-responsive drug system for cancer chemotherapy. | Yu, B., et al. 2018. J Biomed Mater Res A. 106: 3203-3210. PMID: 30242956
- Preparation of thermo/redox/pH-stimulative poly(N-isopropylacrylamide-co-N,N'-dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors. | Gao, D., et al. 2019. J Biomed Mater Res A. 107: 1195-1203. PMID: 30650226
- Formation of enzymatic/redox-switching nanogates on mesoporous silica nanoparticles for anticancer drug delivery. | Luo, W., et al. 2019. Mater Sci Eng C Mater Biol Appl. 100: 855-861. PMID: 30948123
- Preparation and properties of a highly elastic galactomannan- poly(acrylamide- N, N-bis (acryloyl) cysteamine) hydrogel with reductive stimuli-responsive degradable properties. | Gao, Y., et al. 2020. Carbohydr Polym. 231: 115690. PMID: 31888814
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N,N′-Bis(acryloyl)cystamine, 5 g | sc-215506 | 5 g | $410.00 |