Myozenin 2 Antibody (G-2): sc-515000

Myozenin 2 Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects Myozenin 2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Myozenin 2, also known as calsarcin-1, plays a crucial role in muscle function regulation by serving as a key component in the signaling pathway that connects calcineurin, a calcium- and calmodulin-dependent protein phosphatase, to the structural framework of muscle cells. Myozenin 2 is primarily located at the Z-line of the sarcomere, where anti-Myozenin 2 antibody (G-2) can detect binding to calcineurin and α-actinin, facilitating the modulation of gene expression related to slow fiber development in skeletal muscle and hypertrophy in cardiac muscle. Precise localization of Myozenin 2 is vital for maintaining structural integrity and functional capacity of muscle tissues, particularly during embryonic development and in adult cardiac and slow-twitch skeletal muscle. Myozenin 2 gene maps to chromosome 4q and specifically expresses in adult cardiac and slow-twitch skeletal muscle, distinguishing Myozenin 2 from Myozenin 1, which predominantly appears in fast skeletal muscle. This specificity underscores Myozenin 2′s importance in muscle physiology and potential implications in muscle-related diseases, making Myozenin 2 (G-2) antibody an essential tool for researchers studying muscle biology and pathology.

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Myozenin 2 Antibody (G-2) References:

1. Major quantitative trait locus for resting heart rate maps to a region on chromosome 4.  |  Martin, LJ., et al. 2004. Hypertension. 43: 1146-51. PMID: 14993199
2. Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells.  |  Dunckley, T. and Lukas, RJ. 2006. Brain Res. 1116: 39-49. PMID: 16949557
3. Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy.  |  Osio, A., et al. 2007. Circ Res. 100: 766-8. PMID: 17347475
4. A class III PDZ binding motif in the myotilin and FATZ families binds enigma family proteins: a common link for Z-disc myopathies.  |  von Nandelstadh, P., et al. 2009. Mol Cell Biol. 29: 822-34. PMID: 19047374
5. Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity.  |  Ruggiero, A., et al. 2013. Cardiovasc Res. 97: 44-54. PMID: 22987565
6. Cardiac phosphoproteomics during remote ischemic preconditioning: a role for the sarcomeric Z-disk proteins.  |  Abdul-Ghani, S., et al. 2014. Biomed Res Int. 2014: 767812. PMID: 24795895
7. Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms.  |  Zervou, S., et al. 2016. Amino Acids. 48: 1969-81. PMID: 27143170
8. The longissimus thoracis muscle proteome in Alentejana bulls as affected by growth path.  |  Almeida, AM., et al. 2017. J Proteomics. 152: 206-215. PMID: 27816513
9. Systematic Discovery of FBXW7-Binding Phosphodegrons Highlights Mitogen-Activated Protein Kinases as Important Regulators of Intracellular Protein Levels.  |  Singh, N., et al. 2022. Int J Mol Sci. 23: PMID: 35328741
10. Potential links between COVID-19 and periodontitis: a bioinformatic analysis based on GEO datasets.  |  Zhang, C., et al. 2022. BMC Oral Health. 22: 520. PMID: 36414950

The preferred Myozenin 2 antibody is Myozenin 2 Antibody (E-11): sc-377359.