Myofibroblasts Antibody (PR 2D3): sc-53383

Myofibroblasts Antibody (PR 2D3) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Myofibroblasts protein of human origin by immunofluorescence (IF). Anti-Myofibroblasts antibody (PR 2D3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Myofibroblasts are specialized fibroblasts that exhibit characteristics similar to smooth muscle cells and are crucial in processes such as wound healing, tissue repair, and fibrosis. These cells are primarily located in the extracellular matrix of tissues, where they contribute to the structural integrity and mechanical properties of the tissue. Their presence is particularly important in the context of tissue injury, as they facilitate wound contraction and the deposition of extracellular matrix components, which are essential for restoring tissue architecture. Additionally, Myofibroblasts are involved in the secretion of various cytokines and growth factors that modulate the inflammatory response and promote healing. The differentiation of Myofibroblasts from embryological stem cells is influenced by secreted proteins such as stem cell factor and platelet-derived growth factor (PDGF), highlighting their role in both normal physiological processes and pathological conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Myofibroblasts Antibody (PR 2D3) References:

1. Myofibroblasts. I. Paracrine cells important in health and disease.  |  Powell, DW., et al. 1999. Am J Physiol. 277: C1-9. PMID: 10409103
2. Myofibroblasts. II. Intestinal subepithelial myofibroblasts.  |  Powell, DW., et al. 1999. Am J Physiol. 277: C183-201. PMID: 10444394
3. Role of myofibroblasts during normal tissue repair and excessive scarring: interest of their assessment in nephropathies.  |  Badid, C., et al. 2000. Histol Histopathol. 15: 269-80. PMID: 10668216
4. Myofibroblasts: paracrine cells important in health and disease.  |  Powell, DW. 2000. Trans Am Clin Climatol Assoc. 111: 271-92; discussion 292-3. PMID: 10881346
5. Collagen IV synthesis is restricted to the enteroendocrine pathway during multilineage differentiation of human colorectal epithelial stem cells.  |  Kirkland, SC. and Henderson, K. 2001. J Cell Sci. 114: 2055-64. PMID: 11493641
6. Colonic pericrypt sheath cells: characterisation of cell type with new monoclonal antibody.  |  Richman, PI., et al. 1987. J Clin Pathol. 40: 593-600. PMID: 3301906
7. Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity.  |  Schmitt-Gräff, A., et al. 1994. Virchows Arch. 425: 3-24. PMID: 7921410
8. Fibroblasts, myofibroblasts, and wound contraction.  |  Grinnell, F. 1994. J Cell Biol. 124: 401-4. PMID: 8106541
9. [Myofibroblasts. Review out outlook].  |  Meister, P. 1998. Pathologe. 19: 187-93. PMID: 9648143

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Myofibroblasts Antibody (PR 2D3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Myofibroblasts Antibody (PR 2D3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Myofibroblasts Antibody (PR 2D3) Specifications

Alternate Product Name: Myofibroblasts

Product Clone Name: PR 2D3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Myofibroblasts

Epitope Species: human

Product Reactivity/Detection: Myofibroblasts

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Myofibroblasts Antibody (PR 2D3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin