Myoferlin Antibody (D-11): sc-376879
- Myoferlin Antibody (D-11) is a mouse monoclonal IgG1 κ Myoferlin antibody, cited in 8 publications, provided at 200 µg/ml
- raised against amino acids 88-198 mapping near the N-terminus of Myoferlin of human origin
- Myoferlin Antibody (D-11) is recommended for detection of Myoferlin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Myoferlin Antibody (D-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Myoferlin Antibody (D-11). This work is in progress.
QUICK LINKS
SEE ALSO...
Myoferlin Antibody (D-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Myoferlin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Myoferlin antibody (D-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Myoferlin, also known as Fer-1-like protein 3, is a crucial member of the ferlin family of proteins, sharing structural similarities with dysferlin. Myoferlin is primarily located in cardiac and skeletal muscle, where expression occurs predominantly at nuclear and plasma membranes. A unique structure including a single transmembrane domain near the C-terminus, an SH3 domain, and six C2 domains (C2A-C2F) is essential for Myoferlin′s function in calcium-mediated membrane fusion events. These C2 domains suggest a significant role in membrane regeneration and repair, vital for maintaining muscle integrity and function. Myoferlin regulates stability and signaling of Flk-1, vascular endothelial growth factor receptor-2, where loss can lead to impaired proliferation, migration, and nitric oxide release in response to vascular endothelial growth factor. Myoferlin has been implicated in various muscular dystrophies and cardiomyopathies, highlighting importance in muscle health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Myoferlin Antibody (D-11) References:
- Myoferlin, a candidate gene and potential modifier of muscular dystrophy. | Davis, DB., et al. 2000. Hum Mol Genet. 9: 217-26. PMID: 10607832
- OTOF encodes multiple long and short isoforms: genetic evidence that the long ones underlie recessive deafness DFNB9. | Yasunaga, S., et al. 2000. Am J Hum Genet. 67: 591-600. PMID: 10903124
- The third human FER-1-like protein is highly similar to dysferlin. | Britton, S., et al. 2000. Genomics. 68: 313-21. PMID: 10995573
- Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains. | Davis, DB., et al. 2002. J Biol Chem. 277: 22883-8. PMID: 11959863
- Normal myoblast fusion requires myoferlin. | Doherty, KR., et al. 2005. Development. 132: 5565-75. PMID: 16280346
- Expression of myoferlin in skeletal muscles of patients with dysferlinopathy. | Inoue, M., et al. 2006. Tohoku J Exp Med. 209: 109-16. PMID: 16707852
- Mutation impact on dysferlin inferred from database analysis and computer-based structural predictions. | Therrien, C., et al. 2006. J Neurol Sci. 250: 71-8. PMID: 16996541
- Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function. | Bernatchez, PN., et al. 2007. J Biol Chem. 282: 30745-53. PMID: 17702744
- Combined isometric, concentric, and eccentric resistance exercise prevents unloading-induced muscle atrophy in rats. | Adams, GR., et al. 2007. J Appl Physiol (1985). 103: 1644-54. PMID: 17872405
- Myoferlin, a multifunctional protein in normal cells, has novel and key roles in various cancers. | Zhu, W., et al. 2019. J Cell Mol Med. 23: 7180-7189. PMID: 31475450
- Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells. | Rademaker, G., et al. 2022. Redox Biol. 53: 102324. PMID: 35533575
- Identification of myoferlin as a mitochondria-associated membranes component required for calcium signaling in PDAC cell lines. | Anania, S., et al. 2024. Cell Commun Signal. 22: 133. PMID: 38368370
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Myoferlin Antibody (D-11) | sc-376879 | 200 µg/ml | $322.00 | |||
Myoferlin Antibody (D-11) AC | sc-376879 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Myoferlin Antibody (D-11) HRP | sc-376879 HRP | 200 µg/ml | $322.00 | |||
Myoferlin Antibody (D-11) FITC | sc-376879 FITC | 200 µg/ml | $336.00 | |||
Myoferlin Antibody (D-11) PE | sc-376879 PE | 200 µg/ml | $349.00 | |||
Myoferlin Antibody (D-11) Alexa Fluor® 488 | sc-376879 AF488 | 200 µg/ml | $364.00 | |||
Myoferlin Antibody (D-11) Alexa Fluor® 546 | sc-376879 AF546 | 200 µg/ml | $364.00 | |||
Myoferlin Antibody (D-11) Alexa Fluor® 594 | sc-376879 AF594 | 200 µg/ml | $364.00 | |||
Myoferlin Antibody (D-11) Alexa Fluor® 647 | sc-376879 AF647 | 200 µg/ml | $364.00 | |||
Myoferlin Antibody (D-11) Alexa Fluor® 680 | sc-376879 AF680 | 200 µg/ml | $364.00 | |||
Myoferlin Antibody (D-11) Alexa Fluor® 790 | sc-376879 AF790 | 200 µg/ml | $364.00 |