Myosin-2/MYH2 Antibody (A4.1519): sc-53094

MYH2 Antibody (A4.1519) is a mouse monoclonal IgM kappa light chain antibody designed to detect the fast-twitch myosin heavy chain protein encoded by the MYH2 gene, also known as MyHC-IIa, myosin heavy chain 2, or fast IIa myosin heavy chain, in mouse, rat, and human tissues. Anti-MYH2 antibody (A4.1519) targets adult skeletal muscle myosin of human origin and is recommended for use in western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications, ensuring reliable performance across a range of experimental techniques. MYH2 is a critical component of the sarcomeric thick filaments in skeletal muscle fibers, playing an essential role in muscle contraction by interacting with actin filaments to generate the force necessary for movement. MYH2 undergoes significant post-translational modifications, notably phosphorylation of its heavy chain, which modulates ATPase activity and motor function. These modifications are crucial for regulating muscle contraction speed, force generation, and muscle adaptability. Understanding these PTMs is important because they affect muscle performance and can be implicated in muscle-related diseases such as myopathies and muscular dystrophies. MYH2 (A4.1519) antibody facilitates detailed analysis of muscle fiber composition, muscle development, and the molecular mechanisms underlying muscle physiology and pathology.

The preferred antibody is Antibody (): sc-32732m.