MYBBP1A Antibody (170C2R): sc-517621
- MYBBP1A Antibody (170C2R) is a mouse monoclonal IgG1 κ MYBBP1A antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 1104-1328 at the C-terminus of MYBBP1A of human origin
- recommended for detection of MYBBP1A of human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MYBBP1A Antibody (170C2R). This work is in progress.
MYBBP1A Antibody (170C2R) is a mouse monoclonal IgG1 kappa light chain antibody that detects MYBBP1A protein of human origin by western blotting (WB). Anti-MYBBP1A antibody (170C2R) is available as a non-conjugated format. MYBBP1A, also known as MYB binding protein (P160) 1a or P160, is a 1,328 amino acid protein that plays a crucial role in regulating gene expression by interacting with sequence-specific DNA binding proteins, such as c-Jun and c-Myb. This interaction enables MYBBP1A to modulate transcriptional activity, influencing cellular processes like growth, differentiation, and stress response. MYBBP1A is predominantly localized in both nucleus and cytoplasm, with shuttling between these compartments enabling dynamic responses to cellular signals and context-dependent gene expression regulation. MYBBP1A exists as two alternatively spliced isoforms and shares 80% sequence identity with its mouse counterpart, indicating conserved function across species. Given MYBBP1A′s involvement in transcriptional regulation, this protein may play a role in tumor transformation and metastasis, making MYBBP1A an important target for cancer biology research.
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MYBBP1A Antibody (170C2R) References:
- Molecular cloning and chromosomal mapping of the human homologue of MYB binding protein (P160) 1A (MYBBP1A) to 17p13.3. | Keough, R., et al. 1999. Genomics. 62: 483-9. PMID: 10644447
- Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. | Fan, M., et al. 2004. Genes Dev. 18: 278-89. PMID: 14744933
- MYBBP1a is a novel repressor of NF-kappaB. | Owen, HR., et al. 2007. J Mol Biol. 366: 725-36. PMID: 17196614
- Ets-2 and p160 proteins collaborate to regulate c-Myc in endocrine resistant breast cancer. | Al-azawi, D., et al. 2008. Oncogene. 27: 3021-31. PMID: 18059336
- Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. | Lu, Y., et al. 2008. J Lipid Res. 49: 2582-9. PMID: 18660489
- TPPII, MYBBP1A and CDK2 form a protein-protein interaction network. | Nahálková, J. and Tomkinson, B. 2014. Arch Biochem Biophys. 564: 128-35. PMID: 25303791
- c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer. | Felipe-Abrio, B., et al. 2019. Mol Oncol. 13: 1519-1533. PMID: 31066170
- Characterization of the impact of the MYBBP1A gene and rs3809849 on asparaginase sensitivity and cellular functions. | Abaji, R., et al. 2022. Pharmacogenomics. 23: 415-430. PMID: 35485735
- MYBBP1A is required for efficient replication and gene expression of herpes simplex virus 1. | Nobe, M., et al. 2024. Microbiol Immunol. 68: 148-154. PMID: 38402407
- The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury. | Qu, Z., et al. 2024. Redox Biol. 72: 103145. PMID: 38583415
- Detection of proteins that bind to the leucine zipper motif of c-Myb. | Favier, D. and Gonda, TJ. 1994. Oncogene. 9: 305-11. PMID: 8302594
- Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb. | Tavner, FJ., et al. 1998. Mol Cell Biol. 18: 989-1002. PMID: 9447996
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MYBBP1A Antibody (170C2R) | sc-517621 | 100 µg/ml | $322.00 |