MTSS1 Antibody (M7-P3A7): sc-101390

MTSS1 Antibody (M7-P3A7) is a mouse monoclonal IgG1 kappa light chain antibody that detects MTSS1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MTSS1 antibody (M7-P3A7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MTSS1, also known as metastasis suppressor 1, MIM, MIMA, or MIMB, is a 755 amino acid protein characterized by one Actin-binding WH2 (Wiskott-Aldrich syndrome protein homology-2) domain and one IMD domain. MTSS1 is expressed in a variety of tissues, including testis, thymus, prostate, spleen, colon, uterus, and blood, and plays a crucial role in binding to Actin, which is essential for maintaining cytoskeleton dynamics. This interaction influences cellular processes such as migration and adhesion, thereby impacting carcinoma progression and metastasis in various organs. When expressed at normal levels, MTSS1 functions as a tumor suppressor, but overexpression can lead to abnormal actin structure formation, potentially resulting in tumorigenesis. Additionally, three MTSS1 isoforms exist due to alternative splicing events, which may contribute to functional diversity and regulatory mechanisms in cancer biology.

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MTSS1 Antibody (M7-P3A7) References:

1. MIM, a potential metastasis suppressor gene in bladder cancer.  |  Lee, YG., et al. 2002. Neoplasia. 4: 291-4. PMID: 12082544
2. Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain.  |  Mattila, PK., et al. 2003. J Biol Chem. 278: 8452-9. PMID: 12482861
3. MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta.  |  Woodings, JA., et al. 2003. Biochem J. 371: 463-71. PMID: 12570871
4. Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines.  |  Nixdorf, S., et al. 2004. Cancer Lett. 215: 209-20. PMID: 15488640
5. MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription.  |  Callahan, CA., et al. 2004. Genes Dev. 18: 2724-9. PMID: 15545630
6. Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4.  |  Gonzalez-Quevedo, R., et al. 2005. J Cell Biol. 168: 453-63. PMID: 15684034
7. Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B.  |  Bompard, G., et al. 2005. J Cell Sci. 118: 5393-403. PMID: 16280553
8. The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation.  |  Utikal, J., et al. 2006. Int J Cancer. 119: 2287-93. PMID: 16921485
9. Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma.  |  Ma, S., et al. 2007. Hum Pathol. 38: 1201-6. PMID: 17442377
10. MTSS1 and SCAMP1 cooperate to prevent invasion in breast cancer.  |  Vadakekolathu, J., et al. 2018. Cell Death Dis. 9: 344. PMID: 29497041
11. MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias.  |  Brown, AS., et al. 2018. Proc Natl Acad Sci U S A. 115: E12407-E12416. PMID: 30530649
12. circFBXO7/miR-96-5p/MTSS1 axis is an important regulator in the Wnt signaling pathway in ovarian cancer.  |  Wu, M., et al. 2022. Mol Cancer. 21: 137. PMID: 35768865

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MTSS1 Antibody (M7-P3A7) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-MTSS1 Antibody (M7-P3A7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MTSS1 Antibody (M7-P3A7) Specifications

Alternate Product Name: MTSS1

Product Clone Name: M7-P3A7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 679-688

Epitope Target: MTSS1

Epitope Species: human

Product Reactivity/Detection: MTSS1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for MTSS1 Antibody (M7-P3A7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin