MTP Antibody (C-1): sc-515742
- MTP Antibody (C-1) is a mouse monoclonal IgG1 κ MTP antibody, cited in 8 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of MTP of human origin
- MTP Antibody (C-1) is recommended for detection of MTP of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-MTP Antibody (C-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MTP Antibody (C-1) for WB and IHC(P) applications. These reagents are now offered in bundles with MTP Antibody (C-1) (see ordering information below).
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MTP Antibody (C-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects MTP in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-MTP antibody (C-1) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. The microsomal triglyceride transfer protein (MTP) plays a crucial role in lipid metabolism by facilitating the transport of cholesteryl esters, triglycerides, and phospholipids between phospholipid surfaces, which is essential for the assembly and secretion of lipoproteins that contain apolipoprotein B. MTP is a heterodimer composed of MTP and protein disulfide isomerase (PDI), and proper function is vital for maintaining lipid homeostasis in the body. MTP is primarily localized in the endoplasmic reticulum and is predominantly expressed in the small intestine and liver, with additional expression in the kidney, testis, and ovary, but is notably absent in epithelial cells. Dysregulation or defects in MTP can lead to abetalipoproteinemia, an autosomal recessive disorder characterized by impaired lipoprotein metabolism, highlighting MTP′s importance in human health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MTP Antibody (C-1) References:
- Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly. | Hussain, MM., et al. 2003. J Lipid Res. 44: 22-32. PMID: 12518019
- Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism. | Hussain, MM., et al. 2008. Curr Opin Lipidol. 19: 277-84. PMID: 18460919
- Contemporary aspects of the biology and therapeutic regulation of the microsomal triglyceride transfer protein. | Hooper, AJ., et al. 2015. Circ Res. 116: 193-205. PMID: 25552696
- Microsomal Triglyceride Transfer Protein (MTP) Associates with Cytosolic Lipid Droplets in 3T3-L1 Adipocytes. | Love, JD., et al. 2015. PLoS One. 10: e0135598. PMID: 26267806
- Targeting microsomal triglyceride transfer protein and lipoprotein assembly to treat homozygous familial hypercholesterolemia. | Walsh, MT. and Hussain, MM. 2017. Crit Rev Clin Lab Sci. 54: 26-48. PMID: 27690713
- Microsomal triglyceride transfer protein contributes to lipid droplet maturation in adipocytes. | Swift, LL., et al. 2017. PLoS One. 12: e0181046. PMID: 28793320
- The crystal structure of human microsomal triglyceride transfer protein. | Biterova, EI., et al. 2019. Proc Natl Acad Sci U S A. 116: 17251-17260. PMID: 31395737
- Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH. | Simón, J., et al. 2021. J Hepatol. 75: 34-45. PMID: 33571553
- Generation of hepatoma cell lines deficient in microsomal triglyceride transfer protein. | Anaganti, N., et al. 2022. J Lipid Res. 63: 100257. PMID: 35931202
- A coding variant in the microsomal triglyceride transfer protein reduces both hepatic steatosis and plasma lipids. | Schneider, CV., et al. 2023. Aliment Pharmacol Ther. 58: 238-249. PMID: 37248657
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MTP Antibody (C-1) | sc-515742 | 200 µg/ml | $322.00 | |||
MTP Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-528059 | 200 µg Ab; 10 µg BP | $361.00 | |||
MTP Antibody (C-1): m-IgG1 BP-HRP Bundle | sc-533432 | 200 µg Ab; 20 µg BP | $361.00 | |||
MTP Antibody (C-1) AC | sc-515742 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MTP Antibody (C-1) HRP | sc-515742 HRP | 200 µg/ml | $322.00 | |||
MTP Antibody (C-1) FITC | sc-515742 FITC | 200 µg/ml | $336.00 | |||
MTP Antibody (C-1) PE | sc-515742 PE | 200 µg/ml | $349.00 | |||
MTP Antibody (C-1) Alexa Fluor® 488 | sc-515742 AF488 | 200 µg/ml | $364.00 | |||
MTP Antibody (C-1) Alexa Fluor® 546 | sc-515742 AF546 | 200 µg/ml | $364.00 | |||
MTP Antibody (C-1) Alexa Fluor® 594 | sc-515742 AF594 | 200 µg/ml | $364.00 | |||
MTP Antibody (C-1) Alexa Fluor® 647 | sc-515742 AF647 | 200 µg/ml | $364.00 | |||
MTP Antibody (C-1) Alexa Fluor® 680 | sc-515742 AF680 | 200 µg/ml | $364.00 | |||
MTP Antibody (C-1) Alexa Fluor® 790 | sc-515742 AF790 | 200 µg/ml | $364.00 |