MTMR5 Antibody (B-9): sc-393488

MTMR5 Antibody (B-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects MTMR5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MTMR5 (B-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MTMR5 protein is a member of the myotubularin family, which consists of eukaryotic phosphatases that play a crucial role in lipid metabolism by hydrolyzing phosphoinositides, specifically Phosphatidylinositol 3-phosphate and Phosphatidylinositol 4,5-bisphosphate. This enzymatic activity is vital for cellular processes such as membrane trafficking and signal transduction. MTMR5 is known to interact with MTMR2, enhancing enzymatic activity and influencing localization within the cell. Dysregulation of these interactions can lead to significant pathophysiological conditions, such as Charcot-Marie-Tooth disease, highlighting MTMR5′s importance in maintaining cellular homeostasis and nerve function. With broad species reactivity and versatile applications, anti-MTMR5 antibody (B-9) is an essential tool for researchers studying the intricate roles of myotubularins in cellular signaling and disease mechanisms.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

MTMR5 Antibody (B-9) References:

1. Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway.  |  Blondeau, F., et al. 2000. Hum Mol Genet. 9: 2223-9. PMID: 11001925
2. Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase.  |  Kim, SA., et al. 2003. Proc Natl Acad Sci U S A. 100: 4492-7. PMID: 12668758
3. Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.  |  Mochizuki, Y. and Majerus, PW. 2003. Proc Natl Acad Sci U S A. 100: 9768-73. PMID: 12890864
4. Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1.  |  Srivastava, S., et al. 2006. Mol Biol Cell. 17: 146-54. PMID: 16251351
5. Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2.  |  Berger, P., et al. 2006. Hum Mol Genet. 15: 569-79. PMID: 16399794
6. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.  |  Lorenzo, O., et al. 2006. J Cell Sci. 119: 2953-9. PMID: 16787938
7. Mutations in the MTM1 gene implicated in X-linked myotubular myopathy. ENMC International Consortium on Myotubular Myopathy. European Neuro-Muscular Center.  |  Laporte, J., et al. 1997. Hum Mol Genet. 6: 1505-11. PMID: 9305655

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MTMR5 Antibody (B-9) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-MTMR5 Antibody (B-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MTMR5 Antibody (B-9) Specifications

Alternate Product Name: MTMR5

Product Clone Name: B-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1667-1776

Epitope Target: MTMR5

Epitope Species: human

Product Reactivity/Detection: MTMR5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for MTMR5 Antibody (B-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin