MT-MMP-1 (h): 293T Lysate: sc-116661

MT-MMP-1 (h): 293T Lysate, derived from the HEK 293T cell line, is extensively utilized in research focused on Membrane-Type Matrix Metalloproteinase-1 (MT-MMP-1), a critical enzyme in the regulation of extracellular matrix (ECM) remodeling. The 293T cell line, a human embryonic kidney cell variant, has been engineered to express the SV40 large T antigen, which enhances its ability to produce high levels of recombinant proteins. This lysate is particularly valuable for investigating the enzymatic activities and regulatory mechanisms of MT-MMP-1, which is anchored to the cell membrane and involved in the activation of other matrix metalloproteinases (MMPs), as well as direct ECM degradation. Researchers utilize MT-MMP-1 (h): 293T Lysate to study its role in cellular processes such as migration, invasion, and tissue morphogenesis. Techniques like zymography, Western blotting, and immunoprecipitation are commonly employed to analyze the expression, activity, and interactions of MT-MMP-1. Studies often focus on how MT-MMP-1 facilitates cell invasion by degrading ECM components and activating pro-MMP-2 and pro-MMP-13. This research is crucial for understanding the fundamental mechanisms of ECM remodeling and cellular dynamics, strictly within the realm of basic scientific inquiry.