MSL-1 Antibody (C-9): sc-514649

MSL-1 Antibody (C-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects MSL-1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MSL-1 (C-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MSL-1, also known as male-specific lethal 1 homolog (Drosophila) or MSL1L1, is a crucial 614 amino acid nuclear protein that plays a significant role in gene regulation by forming a multisubunit histone acetyltransferase complex with MOF, MSL-1, MSL-2, and MSL3L1. This complex is primarily responsible for the acetylation of histone H4 at lysine 16, a modification essential for gene expression and chromatin structure regulation. MSL-1 maintains genomic stability and prevents various diseases, including cancer, by influencing genes involved in cell cycle regulation and DNA repair. MSL-1 exists in three alternatively spliced isoforms and is encoded by a gene located on human chromosome 17q21.1, a region harboring over 1,200 genes, including key tumor suppressor genes such as p53 and BRCA1. Loss of function or mutation of these genes is associated with various malignancies, highlighting MSL-1′s importance in cellular health and disease prevention.

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MSL-1 Antibody (C-9) References:

1. Characterization of a novel chromo domain gene in xp22.3 with homology to Drosophila msl-3.  |  Prakash, SK., et al. 1999. Genomics. 59: 77-84. PMID: 10395802
2. The role of chromosomal RNAs in marking the X for dosage compensation.  |  Kelley, RL. and Kuroda, MI. 2000. Curr Opin Genet Dev. 10: 555-61. PMID: 10980435
3. Distinct pattern of p53 phosphorylation in human tumors.  |  Minamoto, T., et al. 2001. Oncogene. 20: 3341-7. PMID: 11423984
4. Three primary malignancies related to BRCA mutation successively occurring in a BRCA1 185delAG mutation carrier.  |  Piura, B., et al. 2001. Eur J Obstet Gynecol Reprod Biol. 97: 241-4. PMID: 11451557
5. Evolution of chromatin-remodeling complexes: comparative genomics reveals the ancient origin of 'novel' compensasome genes.  |  Marín, I. 2003. J Mol Evol. 56: 527-39. PMID: 12698291
6. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16.  |  Smith, ER., et al. 2005. Mol Cell Biol. 25: 9175-88. PMID: 16227571
7. p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage.  |  Gironella, M., et al. 2009. J Cell Physiol. 221: 594-602. PMID: 19650074
8. MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.  |  Sharma, GG., et al. 2010. Mol Cell Biol. 30: 3582-95. PMID: 20479123
9. The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.  |  Wu, L., et al. 2011. Mol Cell. 43: 132-44. PMID: 21726816
10. Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and Long Noncoding RNAs.  |  Samata, M. and Akhtar, A. 2018. Annu Rev Biochem. 87: 323-350. PMID: 29668306
11. The Li-Fraumeni syndrome: an inherited susceptibility to cancer.  |  Evans, SC. and Lozano, G. 1997. Mol Med Today. 3: 390-5. PMID: 9302689
12. Loss of heterozygosity for defined regions on chromosomes 3, 11 and 17 in carcinomas of the uterine cervix.  |  Kersemaekers, AM., et al. 1998. Br J Cancer. 77: 192-200. PMID: 9460988

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MSL-1 Antibody (C-9) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-MSL-1 Antibody (C-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MSL-1 Antibody (C-9) Specifications

Alternate Product Name: MSL-1

Product Clone Name: C-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 584-603

Epitope Target: MSL-1

Epitope Species: human

Product Reactivity/Detection: MSL-1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for MSL-1 Antibody (C-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin