MSK1 Antibody (D-77): sc-130431
- MSK1 Antibody (D-77) is a mouse monoclonal IgG2b λ MSK1 antibody, cited in 1 publications, provided at 100 µg/ml
- raised against a partial recombinant protein mapping within amino acids 271-370 of MSK1 of human origin
- recommended for detection of MSK1 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MSK1 Antibody (D-77). This work is in progress.
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MSK1 Antibody (D-77) is a mouse monoclonal IgG2b antibody that detects MSK1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-MSK1 antibody (D-77) is available as a non-conjugated format and plays a crucial role in studying cellular signaling pathways. MSK1, also known as Ribosomal Protein S6 Kinase A5, is a key player in the mitogen-activated protein kinase (MAPK) signaling cascade, which is essential for various cellular processes, including cell growth, differentiation, and response to stress. MSK1 phosphorylates histone H3 and other substrates, thereby influencing gene expression and chromatin remodeling. This post-translational modification regulates transcriptional responses to extracellular signals, making MSK1 an important target for understanding cancer biology and other diseases linked to aberrant signaling pathways. MSK1 shares structural similarities with other ribosomal S6 kinase family members, which mediate cellular responses to growth factors and stress signals, highlighting MSK1′s importance in cellular homeostasis and signaling.
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MSK1 Antibody (D-77) References:
- Emerging Roles of the Mitogen and Stress Activated Kinases MSK1 and MSK2. | Reyskens, KM. and Arthur, JS. 2016. Front Cell Dev Biol. 4: 56. PMID: 27376065
- Overexpression of MSK1 is associated with tumor aggressiveness and poor prognosis in colorectal cancer. | Fu, X., et al. 2017. Dig Liver Dis. 49: 683-691. PMID: 28314603
- Illuminating MSK1's role in tumour dormancy. | Grzelak, CA. and Ghajar, CM. 2018. Nat Cell Biol. 20: 124-126. PMID: 29371707
- MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression. | Ahn, J., et al. 2018. Exp Mol Med. 50: 1-12. PMID: 30305627
- Novel Insights into MSK1 Phosphorylation by MRKβ in Intracerebral Hemorrhage-Induced Neuronal Apoptosis. | Gong, P., et al. 2019. Cell Transplant. 28: 783-795. PMID: 30744416
- MSK1 promotes cell proliferation and metastasis in uveal melanoma by phosphorylating CREB. | Li, J., et al. 2020. Arch Med Sci. 16: 1176-1188. PMID: 32864007
- MSK1 downregulation is involved in inflammatory responses following subarachnoid hemorrhage in rats. | Ning, B., et al. 2021. Exp Ther Med. 21: 364. PMID: 33732337
- Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states. | Sattarifard, H., et al. 2023. Biochem Cell Biol. 101: 204-219. PMID: 36812480
- HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B. | Malvi, P., et al. 2023. Cell Rep Med. 4: 101285. PMID: 37951219
- Exosomal miR-155-5p drives widespread macrophage M1 polarization in hypervirulent Klebsiella pneumoniae-induced acute lung injury via the MSK1/p38-MAPK axis. | Xu, Y., et al. 2023. Cell Mol Biol Lett. 28: 92. PMID: 37953267
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MSK1 Antibody (D-77) | sc-130431 | 100 µg/ml | $339.00 |