MSH2 Antibody (E-7): sc-365052
- MSH2 Antibody (E-7) is a mouse monoclonal IgG3 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-28 at the N-terminus of MSH2 of human origin
- recommended for detection of MSH2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- m-IgG3 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MSH2 Antibody (E-7) for WB applications. These reagents are now offered in bundles with MSH2 Antibody (E-7) (see ordering information below).
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MSH2 Antibody (E-7) is a mouse monoclonal IgG3 antibody that detects MSH2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MSH2 plays a crucial role in the DNA mismatch repair (MMR) pathway, which is essential for maintaining genomic stability by correcting errors that occur during DNA replication. MSH2 (E-7) antibody enables detection of deficiencies that can lead to an accumulation of mutations, contributing to the development of various cancers, including hereditary nonpolyposis colorectal cancer (HNPCC). MSH2 forms a heterodimer with MSH6 or MSH3 to recognize and bind to mismatched DNA, initiating the repair process. The significance of MSH2 in cancer biology is underscored by mutations in this gene being prevalent in HNPCC and observed in a range of other malignancies, indicating broader implications in tumorigenesis. Anti-MSH2 antibody (E-7) serves as an invaluable tool for researchers investigating the mechanisms of DNA repair and MSH2′s role in cancer development.
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MSH2 Antibody (E-7) References:
- MSH2 Loss in Primary Prostate Cancer. | Guedes, LB., et al. 2017. Clin Cancer Res. 23: 6863-6874. PMID: 28790115
- MSH2 shapes the meiotic crossover landscape in relation to interhomolog polymorphism in Arabidopsis. | Blackwell, AR., et al. 2020. EMBO J. 39: e104858. PMID: 32935357
- OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination. | Wu, Q., et al. 2021. J Biol Chem. 296: 100466. PMID: 33640455
- CircLIFR synergizes with MSH2 to attenuate chemoresistance via MutSα/ATM-p73 axis in bladder cancer. | Zhang, H., et al. 2021. Mol Cancer. 20: 70. PMID: 33874956
- Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair. | DuPrie, ML., et al. 2022. DNA Repair (Amst). 119: 103405. PMID: 36122480
- MSH2 is the very young onset ovarian cancer predisposition gene, not BRCA1. | Flaum, N., et al. 2023. J Med Genet. 60: 576-577. PMID: 36894311
- Correlation of MLH1 and MSH2 levels with clinicopathologic characteristics in colorectal cancer. | Guo, L., et al. 2023. Am J Transl Res. 15: 1107-1116. PMID: 36915797
- MSH2 stimulates interfering and inhibits non-interfering crossovers in response to genetic polymorphism. | Dluzewska, J., et al. 2023. Nat Commun. 14: 6716. PMID: 37872134
- Functional and phenotypic consequences of an unusual inversion in MSH2. | Pelletier, D., et al. 2024. Fam Cancer. 23: 1-7. PMID: 37957483
- Lnc-PTCHD4-AS inhibits gastric cancer through MSH2-MSH6 dimerization and ATM-p53-p21 activation. | Wang, J., et al. 2023. Aging (Albany NY). 15: 13558-13578. PMID: 38016120
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MSH2 Antibody (E-7) | sc-365052 | 200 µg/ml | $322.00 | |||
MSH2 Antibody (E-7): m-IgGκ BP-HRP Bundle | sc-535139 | 200 µg Ab; 40 µg BP | $361.00 | |||
MSH2 Antibody (E-7): m-IgG3 BP-HRP Bundle | sc-550306 | 200 µg Ab; 40 µg BP | $361.00 | |||
MSH2 (E-7) Neutralizing Peptide | sc-365052 P | 100 µg/0.5 ml | $69.00 |