MRT67307 (CAS 1190378-57-4)
Alternate Names:
MRT-67307 MRT 67307 MEY37JZ4XR N-[3-[[5-cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide
CAS Number:
1190378-57-4
Molecular Weight:
464.60
Molecular Formula:
C26H36N6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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MRT67307 (CAS 1190378-57-4) References
- Novel cross-talk within the IKK family controls innate immunity. | Clark, K., et al. 2011. Biochem J. 434: 93-104. PMID: 21138416
- Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. | Petherick, KJ., et al. 2015. J Biol Chem. 290: 11376-83. PMID: 25833948
- Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study. | Lork, M., et al. 2018. Front Cell Dev Biol. 6: 40. PMID: 29755980
- Interferon-induced transmembrane protein 1 and Myxovirus resistance protein 1 are induced by polyinosinic-polycytidylic acid in cultured hCMEC/D3 human cerebral microvascular endothelial cells. | Imaizumi, T., et al. 2019. J Neuroimmunol. 337: 577047. PMID: 31520792
- Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL). | Xu, X., et al. 2020. Cell Death Dis. 11: 94. PMID: 32024820
- Polyinosinic-Polycytidylic Acid Induces CXCL1 Expression in Cultured hCMEC/D3 Human Cerebral Microvascular Endothelial Cells. | Li, Y., et al. 2020. Neuroimmunomodulation. 27: 38-47. PMID: 32294654
- PAWI-2 overcomes tumor stemness and drug resistance via cell cycle arrest in integrin β3-KRAS-dependent pancreatic cancer stem cells. | Cheng, J. and Cashman, JR. 2020. Sci Rep. 10: 9162. PMID: 32514015
- DNA damage-triggered activation of cGAS-STING pathway induces apoptosis in human keratinocyte HaCaT cells. | Li, C., et al. 2021. Mol Immunol. 131: 180-190. PMID: 33423764
- Exploring the stability of inhibitor binding to SIK2 using molecular dynamics simulation and binding free energy calculation. | Shi, M., et al. 2021. Phys Chem Chem Phys. 23: 13216-13227. PMID: 34086021
- Therapeutic targeting of TANK-binding kinase signaling towards anticancer drug development: Challenges and opportunities. | Alam, M., et al. 2022. Int J Biol Macromol. 207: 1022-1037. PMID: 35358582
- TBK1 inhibitors enhance transfection efficiency by suppressing p62/SQSTM1 phosphorylation. | Tsuchiya, M., et al. 2023. Genes Cells. 28: 68-77. PMID: 36284367
- Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection. | Ullah, TR., et al. 2023. Nat Commun. 14: 5666. PMID: 37723181
- Ginsenoside Rg5 enhances the radiosensitivity of lung adenocarcinoma via reducing HSP90-CDC37 interaction and promoting client protein degradation. | Bai, H., et al. 2023. J Pharm Anal. 13: 1296-1308. PMID: 38174116
Inhibitor of:
AQR, ARRDC3, Atg13, IKK gamma, IKKγ, OXSR1, RNF31, SNX17, SNX20, TBK1, TBKBP1, TICAM-1, TRAF5, ULK1, and ULK2.Activator of:
Tak1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRT67307, 10 mg | sc-507433 | 10 mg | $234.00 |