Molecular structure of MRS 2395, CAS Number: 491611-55-3
MRS 2395 (CAS 491611-55-3)
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Application:
MRS 2395 is an antagonist of the P2Y12 purinoceptor
CAS Number:
491611-55-3
Molecular Weight:
439.94
Molecular Formula:
C20H30ClN5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MRS 2395 is an antagonist for the P2Y12 purinoceptor, which causes platelet aggregation in rats via ADP induction. Studies indicate that MRS 2395 reverses the inhibition of cAMP in rat and human platelets by antagonizing the effects of ADP on cAMP in the presence of PGE. It is known that this inhibition occurs without affecting the purinoceptor P2Y1 in transfected astrocytoma cells.
MRS 2395 (CAS 491611-55-3) References
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- Inhibitory purinergic transmission in mouse caecum: role for P2Y1 receptors as prejunctional modulators of ATP release. | Zizzo, MG., et al. 2007. Neuroscience. 150: 658-64. PMID: 17997228
- A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain. | Andó, RD., et al. 2010. Br J Pharmacol. 159: 1106-17. PMID: 20136836
- Cysteinyl leukotrienes acting via granule membrane-expressed receptors elicit secretion from within cell-free human eosinophil granules. | Neves, JS., et al. 2010. J Allergy Clin Immunol. 125: 477-82. PMID: 20159258
- Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate and 2-methylthioadenosine-5'-diphosphate: mechanisms involved. | Quintas, C., et al. 2011. Neuroscience. 182: 32-42. PMID: 21419195
- Temporal and pharmacological characterization of angiostatin release and generation by human platelets: implications for endothelial cell migration. | Radziwon-Balicka, A., et al. 2013. PLoS One. 8: e59281. PMID: 23555012
- P2Y13 receptor-mediated rapid increase in intracellular calcium induced by ADP in cultured dorsal spinal cord microglia. | Zeng, J., et al. 2014. Neurochem Res. 39: 2240-50. PMID: 25186167
- Leukotriene E4 induces MUC5AC release from human airway epithelial NCI-H292 cells. | Shirasaki, H., et al. 2015. Allergol Int. 64: 169-74. PMID: 25838093
- P2Y13 receptors mediate presynaptic inhibition of acetylcholine release induced by adenine nucleotides at the mouse neuromuscular junction. | Guarracino, JF., et al. 2016. Neuroscience. 326: 31-44. PMID: 27058149
- Involvement of Microglial P2Y12 Signaling in Tongue Cancer Pain. | Tamagawa, T., et al. 2016. J Dent Res. 95: 1176-82. PMID: 27151915
- P2Y12 receptor-mediated activation of spinal microglia and p38MAPK pathway contribute to cancer-induced bone pain. | Liu, M., et al. 2017. J Pain Res. 10: 417-426. PMID: 28243146
- Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395. | Mitrugno, A., et al. 2018. Platelets. 29: 383-394. PMID: 28523947
- P2Y12 regulates microglia activation and excitatory synaptic transmission in spinal lamina II neurons during neuropathic pain in rodents. | Yu, T., et al. 2019. Cell Death Dis. 10: 165. PMID: 30778044
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Inhibitor of:
P2Y12, and P2Y7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRS 2395, 5 mg | sc-253059 | 5 mg | $267.00 |