MRP6 Antibody (M6II-31): sc-59618
- MRP6 Antibody (M6II-31) is a rat monoclonal IgG2a, cited in 5 publications, provided at 500 µl supernatant
- raised against a bacterial fusion protein mapping to amino acids 764-964 of MRP6 of human origin
- recommended for detection of MRP6 of human origin by WB, IF and IHC(P); non cross-reactive with MDR1, MRP1, MRP2 or MRP3, MRP4 and MRP5
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MRP6 Antibody (M6II-31). This work is in progress.
MRP6 Antibody (M6II-31) is a rat monoclonal IgG2a antibody that detects MRP6 of human origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-MRP6 antibody (M6II-31) is available in a non-conjugated form, allowing for versatile applications in research. MRP6, a member of the ATP-binding cassette (ABC) transporter family, plays a crucial role in the transport of various substrates across cellular membranes, which is vital for maintaining cellular homeostasis and drug resistance in cancer cells. MRP6 is predominantly expressed in the liver and kidney, where MRP6 facilitates the excretion of organic anions and xenobiotics, thereby influencing pharmacokinetics and the efficacy of therapeutic agents. Proper functioning of MRP6 is essential, as dysregulation can lead to altered drug metabolism and contribute to multidrug resistance, a significant challenge in cancer treatment. Understanding MRP6 expression and function can provide insights into its role in drug disposition and potential therapeutic strategies to overcome resistance mechanisms.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRP6 Antibody (M6II-31) | sc-59618 | 500 µl supernatant | $322.00 |