MRP3 Antibody (M3II-21): sc-59612

MRP3 Antibody (M3II-21) is a mouse monoclonal IgG2b antibody that detects MRP3 protein of mouse, rat, and human origin by western blotting (WB), immunofluorescence (IF), and flow cytometry (FCM). Anti-MRP3 antibody (M3II-21) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. MRP3, a member of the ATP-binding cassette (ABC) transporter family, plays a crucial role in the cellular export of organic anions, particularly in the liver, where MRP3 is predominantly expressed at the basolateral membrane of hepatocytes. This localization is significant because MRP3 facilitates the transport of various endogenous and exogenous compounds, including drugs and metabolites, from the liver into the bloodstream. MRP3 expression regulation is particularly important in the context of drug resistance, as MRP3 levels can increase when the function of other transporters, such as MRP2, is compromised. Understanding the dynamics of MRP3 expression and function can provide insights into the mechanisms of multidrug resistance in cancer and other diseases, making MRP3 (M3II-21) antibody an essential tool for researchers investigating these critical pathways.

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MRP3 Antibody (M3II-21) References:

1. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane.  |  König, J., et al. 1999. Hepatology. 29: 1156-63. PMID: 10094960
2. MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte.  |  Ortiz, DF., et al. 1999. Am J Physiol. 276: G1493-500. PMID: 10362653
3. Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene.  |  Stöckel, B., et al. 2000. Eur J Biochem. 267: 1347-58. PMID: 10691972
4. Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice.  |  Kruh, GD., et al. 2007. Cancer Metastasis Rev. 26: 5-14. PMID: 17273943
5. The roles of MRP2, MRP3, OATP1B1, and OATP1B3 in conjugated hyperbilirubinemia.  |  Keppler, D. 2014. Drug Metab Dispos. 42: 561-5. PMID: 24459177
6. Mrp3 Transports Clopidogrel Acyl Glucuronide from the Hepatocytes into Blood.  |  Ji, JZ., et al. 2018. Drug Metab Dispos. 46: 151-154. PMID: 29196299
7. Overexpression of MRP3 in HeLa-UGT1A9 Cells Enhances Glucuronidation Capability of the Cells.  |  Zhou, Q., et al. 2021. Curr Drug Metab. 22: 772-783. PMID: 34279197
8. Sensitizing cholangiocarcinoma to chemotherapy by inhibition of the drug-export pump MRP3.  |  Asensio, M., et al. 2024. Biomed Pharmacother. 180: 117533. PMID: 39405909
9. Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein.  |  Versantvoort, CH., et al. 1995. Br J Cancer. 72: 82-9. PMID: 7599070
10. Hepatic canalicular membrane 5: Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver.  |  Keppler, D. and Konig, J. 1997. FASEB J. 11: 509-16. PMID: 9212074
11. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.  |  Kool, M., et al. 1997. Cancer Res. 57: 3537-47. PMID: 9270026
12. Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain.  |  Bakos, E., et al. 1998. J Biol Chem. 273: 32167-75. PMID: 9822694

The preferred MRP3 antibody is MRP3 Antibody (B-2): sc-518159.