MRP2 Antibody (M2 III-6): sc-59608
- MRP2 Antibody (M2 III-6) is a mouse monoclonal IgG2a, cited in 10 publications, provided at 50 µg/0.5 ml
- raised against a C-terminal region of MRP2 of human origin
- recommended for detection of MRP2 of human origin by WB, IF and IHC(P); non cross-reactive with human MDR 1, MRP 1, MRP 3 or MRP 5 gene products
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MRP2 Antibody (M2 III-6). This work is in progress.
MRP2 Antibody (M2 III-6) is a mouse monoclonal IgG2a antibody that detects MRP2 of human origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-MRP2 antibody (M2 III-6) is available in a non-conjugated form, allowing for versatile applications in research. MRP2, also known as canalicular multispecific organic anion transporter (cMOAT), plays a crucial role in the excretion of various organic anions and drugs from hepatocytes into bile, thereby contributing to the detoxification processes in the liver. MRP2 is predominantly localized to the apical membrane of hepatocytes, where high expression is essential for maintaining proper bile flow and preventing the accumulation of potentially harmful substances. MRP2 functionality is particularly important in the context of drug metabolism and resistance, as MRP2 helps regulate the levels of therapeutic agents and their metabolites in the body. Dysregulation or impairment of MRP2 can lead to significant clinical implications, including drug-induced liver injury and altered pharmacokinetics of various medications. Understanding MRP2 expression and function is vital for developing strategies to overcome multidrug resistance in cancer therapy and for optimizing drug delivery systems.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MRP2 Antibody (M2 III-6) References:
- MRP2 and 3 in health and disease. | Borst, P., et al. 2006. Cancer Lett. 234: 51-61. PMID: 16387425
- The roles of MRP2, MRP3, OATP1B1, and OATP1B3 in conjugated hyperbilirubinemia. | Keppler, D. 2014. Drug Metab Dispos. 42: 561-5. PMID: 24459177
- Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis. | Chai, J., et al. 2015. J Hepatol. 63: 1440-8. PMID: 26212029
- Dihydromyricetin reverses MRP2-induced multidrug resistance by preventing NF-κB-Nrf2 signaling in colorectal cancer cell. | Wang, Z., et al. 2021. Phytomedicine. 82: 153414. PMID: 33461143
- 4-Phenylbutyrate protects against rifampin-induced liver injury via regulating MRP2 ubiquitination through inhibiting endoplasmic reticulum stress. | Chen, J., et al. 2022. Bioengineered. 13: 2866-2877. PMID: 35045794
- FOXA2 prevents hyperbilirubinaemia in acute liver failure by maintaining apical MRP2 expression. | Wang, S., et al. 2023. Gut. 72: 549-559. PMID: 35444014
- Slug Mediates MRP2 Expression in Non-Small Cell Lung Cancer Cells. | Zhang, X., et al. 2022. Biomolecules. 12: PMID: 35740931
- Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes. | Zhao, Z., et al. 2024. Chem Res Toxicol. 37: 57-71. PMID: 38177062
- Structural basis for the modulation of MRP2 activity by phosphorylation and drugs. | Mazza, T., et al. 2024. Nat Commun. 15: 1983. PMID: 38438394
- Extracellular Vesicles as Surrogates for the Regulation of the Drug Transporters ABCC2 (MRP2) and ABCG2 (BCRP). | Rigalli, JP., et al. 2024. Int J Mol Sci. 25: PMID: 38612927
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRP2 Antibody (M2 III-6) | sc-59608 | 50 µg/0.5 ml | $316.00 |