MRP2 Antibody (6D564): sc-71603
- MRP2 Antibody (6D564) is a mouse monoclonal IgG1, cited in 3 publications, provided at 500 µl supernatant
- raised against amino acids 215-310 of MRP2 of human origin
- recommended for detection of MRP2 of human origin by WB, IP and IF; non cross-reactive with MDR1, MRP1, MRP3 or MRP5
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MRP2 Antibody (6D564). This work is in progress.
MRP2 Antibody (6D564) is a mouse monoclonal IgG1 antibody that detects MRP2 of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-MRP2 antibody (6D564) is available as the non-conjugated form. MRP2, also known as canalicular multispecific organic anion transporter (cMOAT), plays a crucial role in the excretion of various organic anions, including drugs and their metabolites, from hepatocytes into bile. This function is particularly important in drug metabolism and detoxification, as MRP2 helps regulate levels of potentially harmful substances in the body. MRP2 is predominantly localized to the apical membrane of liver cells, where MRP2 facilitates the transport of conjugated compounds, contributing to the body′s ability to eliminate xenobiotics and endogenous waste products. Proper functioning of MRP2 is essential for maintaining hepatic health and preventing drug-induced liver injury, making MRP2 a significant target for research in pharmacology and toxicology. The MRP gene family includes other members such as MRP1 and MRP3, which also participate in multidrug resistance mechanisms, highlighting the interconnected roles of these transporters in cellular homeostasis and drug disposition.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRP2 Antibody (6D564) | sc-71603 | 500 µl supernatant | $322.00 |