MRP-L49 Antibody (G-11): sc-515160
- MRP-L49 Antibody (G-11) is a mouse monoclonal IgG1 κ MRP-L49 antibody provided at 200 µg/ml
- raised against amino acids 24-166 mapping at the C-terminus of MRP-L49 of human origin
- MRP-L49 Antibody (G-11) is recommended for detection of MRP-L49 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MRP-L49 Antibody (G-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MRP-L49 Antibody (G-11) for WB applications. These reagents are now offered in bundles with MRP-L49 Antibody (G-11) (see ordering information below).
MRP-L49 Antibody (G-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects MRP-L49 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MRP-L49 (G-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MRP-L49, also known as mitochondrial ribosomal protein L49, Neighbor of FAU, and Protein NOF1, is a crucial component of the mitochondrial ribosome, specifically part of the large 39S subunit, which plays a vital role in mitochondrial protein synthesis. This 166 amino acid protein is encoded by a gene located on human chromosome 11, a region associated with several genetic disorders, including Jervell and Lange-Nielsen syndrome and Jacobsen syndrome. Proper functioning of MRP-L49 is essential for the synthesis of mitochondrial proteins, which are critical for energy production and cellular metabolism. Disruptions in the expression or function of MRP-L49 can lead to significant metabolic dysfunctions, highlighting its importance in maintaining cellular health and energy homeostasis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MRP-L49 Antibody (G-11) References:
- Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. | Suzuki, T., et al. 2001. J Biol Chem. 276: 21724-36. PMID: 11279069
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. | Kenmochi, N., et al. 2001. Genomics. 77: 65-70. PMID: 11543634
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Gerhard, DS., et al. 2004. Genome Res. 14: 2121-7. PMID: 15489334
- Nuclear MRP genes and mitochondrial disease. | O'Brien, TW., et al. 2005. Gene. 354: 147-51. PMID: 15908146
- Genomic analysis of the Opi- phenotype. | Hancock, LC., et al. 2006. Genetics. 173: 621-34. PMID: 16582425
- Isolation, cDNA, and genomic structure of a conserved gene (NOF) at chromosome 11q13 next to FAU and oriented in the opposite transcriptional orientation. | Kas, K., et al. 1996. Genomics. 34: 433-6. PMID: 8786148
- Mitochondrial ribosomal proteins (MRPs) of yeast. | Graack, HR. and Wittmann-Liebold, B. 1998. Biochem J. 329 (Pt 3): 433-48. PMID: 9445368
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRP-L49 Antibody (G-11) | sc-515160 | 200 µg/ml | $322.00 | |||
MRP-L49 Antibody (G-11): m-IgG Fc BP-HRP Bundle | sc-527994 | 200 µg Ab; 10 µg BP | $361.00 | |||
MRP-L49 Antibody (G-11): m-IgG1 BP-HRP Bundle | sc-533367 | 200 µg Ab; 20 µg BP | $361.00 | |||
MRP-L49 Antibody (G-11) AC | sc-515160 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MRP-L49 Antibody (G-11) HRP | sc-515160 HRP | 200 µg/ml | $322.00 | |||
MRP-L49 Antibody (G-11) FITC | sc-515160 FITC | 200 µg/ml | $336.00 | |||
MRP-L49 Antibody (G-11) PE | sc-515160 PE | 200 µg/ml | $349.00 | |||
MRP-L49 Antibody (G-11) Alexa Fluor® 488 | sc-515160 AF488 | 200 µg/ml | $364.00 | |||
MRP-L49 Antibody (G-11) Alexa Fluor® 546 | sc-515160 AF546 | 200 µg/ml | $364.00 | |||
MRP-L49 Antibody (G-11) Alexa Fluor® 594 | sc-515160 AF594 | 200 µg/ml | $364.00 | |||
MRP-L49 Antibody (G-11) Alexa Fluor® 647 | sc-515160 AF647 | 200 µg/ml | $364.00 | |||
MRP-L49 Antibody (G-11) Alexa Fluor® 680 | sc-515160 AF680 | 200 µg/ml | $364.00 | |||
MRP-L49 Antibody (G-11) Alexa Fluor® 790 | sc-515160 AF790 | 200 µg/ml | $364.00 |